Results 31 to 40 of about 178,978 (170)

Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate

Journal of Lipid Research
Mitochondria can contact lipid droplets (LDs) to form peridroplet mitochondria (PDM) which trap fatty acids in LDs by providing ATP for triglyceride synthesis and prevent lipotoxicity.
Xiangyun Sun, Qinghong Yu, Yifei Qi, Bilian Kang, Xinyan Zhao, Lin Liu, Ping Wang, Min Cong, Tianhui Liu   +8 more
doaj   +1 more source

Identification of (Z)-2,3-Diphenylacrylonitrile as Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva

Marine Drugs, 2017
Hepatocellular carcinoma (HCC), also named cancerous hepatoma, is the most common type of malignant neoplasia of the liver. In this research, we screened the Persian Gulf sea cucumber Holothuria parva (H.
Salimeh Amidi, Zahra Hashemi, Abbasali Motallebi, Melika Nazemi, Hoda Farrokhpayam, Enayatollah Seydi, Jalal Pourahmad   +6 more
doaj   +1 more source

Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger?

Cells, 2021
Liver injury in COVID-19 patients has progressively emerged, even in those without a history of liver disease, yet the mechanism of liver pathogenicity is still controversial.
Franca Del Nonno, Roberta Nardacci, Daniele Colombo, Ubaldo Visco-Comandini, Stefania Cicalini, Andrea Antinori, Luisa Marchioni, Gianpiero D’Offizi, Mauro Piacentini, Laura Falasca   +9 more
doaj   +1 more source

Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice

Biological Research, 2014
BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis ...
María G Soto-Urquieta, Sergio López-Briones, Victoriano Pérez-Vázquez, Alfredo Saavedra-Molina, Gloria A González-Hernández, Joel Ramírez-Emiliano   +5 more
doaj   +1 more source

Proteomic and metabolomic analysis on cadmium-induced mitochondrial toxicity in liver tissues of juvenile olive flounder Paralichthys olivaceus

Frontiers in Marine Science, 2022
IntroductionCadmium (Cd) is one of the most dominant heavy metals in the Bohai Sea. Our previous study proved that Cd could induce gill mitochondrial toxicity in marine animals.
Zhen Lu, Zhen Lu, Zeyu Xiao, Sihan Wu, Jun Song, Xiao Peng   +5 more
doaj   +1 more source

THE OXIDATION OF GLUTAMATE BY RAT-LIVER MITOCHONDRIA [PDF]

Biochemical Journal, 1965
1. In rat-liver mitochondria both the dehydrogenase and transaminase routes participate in glutamate oxidation. However, the rate of ammonia production by the dehydrogenase pathway progressively decreases with the time of incubation. 2. Glutamate deamination is stimulated by blocking the transaminase pathway with arsenite or malonate. On the other hand,
E, QUAGLIARIELLO, S, PAPA, C, SACCONE, F, PALMIERI, A, FRANCAVILLA   +4 more
openaire   +2 more sources

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

Frontiers in Pharmacology, 2018
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe. Although significant progress has been made in understanding the molecular mechanisms underlying
Anna Moles, Anna Moles, Sandra Torres, Sandra Torres, Anna Baulies, Anna Baulies, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa   +11 more
doaj   +1 more source

Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish

Cell Death Discovery, 2021
MVP17 encodes a mitochondrial inner-membrane protein, and mutation of human MVP17 can cause mitochondria DNA depletion syndrome (MDDS). However, the underlying function of mpv17 is still elusive.
Wan-Ping Bian, Shi-Ya Pu, Shao-Lin Xie, Chao Wang, Shun Deng, Phyllis R. Strauss, De-Sheng Pei   +6 more
doaj   +1 more source

Unravelling the gut-liver axis: The role of gut microbiota-mitochondria interactions in the pathogenesis and management of metabolic-associated fatty liver disease (MAFLD)

Journal of Holistic Integrative Pharmacy
Metabolic-associated fatty liver disease (MAFLD) has emerged as a prevalent chronic liver disease. Our review of the existing literature reveals that the interplay between gut microbiota, mitochondria, and the liver is a key mechanism in the development ...
Binzhi Zhang, Xia Luo, Song Lei, Wenbo Gao, Zhipeng Chen, Qing Zhu, Lizheng Huang, Qinqiang Long   +7 more
doaj   +1 more source

Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation

Biology Open, 2015
Saponin permeabilization of tissue slices is increasingly popular for characterizing mitochondrial function largely because it is fast, easy, requires little tissue and leaves much of the cell intact. This technique is well described for mammalian muscle
Katherine E. Mathers, James F. Staples
doaj   +1 more source