Results 41 to 50 of about 178,978 (170)

D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

Nutrition & Metabolism, 2012
Background Substantially elevated blood D-lactate (DLA) concentrations are associated with neurocardiac toxicity in humans and animals. The neurological symptoms are similar to inherited or acquired abnormalities of pyruvate metabolism.
Ling Binbing, Peng Fei, Alcorn Jane, Lohmann Katharina, Bandy Brian, Zello Gordon A   +5 more
doaj   +1 more source

Reproduction Does Not Adversely Affect Liver Mitochondrial Respiratory Function but Results in Lipid Peroxidation and Increased Antioxidants in House Mice. [PDF]

PLoS ONE, 2016
Reproduction is thought to come at a cost to longevity. Based on the assumption that increased energy expenditure during reproduction is associated with increased free-radical production by mitochondria, oxidative damage has been suggested to drive this ...
Annelise V Mowry, Andreas N Kavazis, Aubrey E Sirman, Wayne K Potts, Wendy R Hood   +4 more
doaj   +1 more source

Alanine Metabolism in Rat Liver Mitochondria [PDF]

European Journal of Biochemistry, 1978
In the presence of 2‐oxoglutarate, bicarbonate, Pi and ATP, rat liver mitochondria were found to metabolize alanine. The main products were glutamate, aspartate, malate and citrate. Pyruvate did not accumulate but reached a low steady‐state concentration. Addition of octanoate caused a strong stimulation of alanine metabolism and a concomitant decrease
P, Dieterle, F, Brawand, U K, Moser, P, Walter   +3 more
openaire   +2 more sources

In vivo identification of bioactive components of Poria cocos for adjusting mitochondria against metabolic dysfunction-associated fatty liver disease

Heliyon
Currently, no specific treatment exists to alleviate metabolic dysfunction-associated fatty liver (MAFLD). Previously, Poria cocos (PC) effectively relieved MAFLD, but its bioactive components are still unknown.
Yanjuan Li, Pengquan Wang, Huan Yang, Jinbiao He, Yu Yang, Yuxuan Tao, Min Zhang, Mei Zhang, Jie Yu, Xingxin Yang   +9 more
doaj   +1 more source

Effect of Hexavalent Chromium on Electron Leakage of Respiratory Chain in Mitochondria Isolated from Rat Liver

Cellular Physiology and Biochemistry, 2013
Background/Aims: In the present study, we explored reactive axygen species (ROS) production in mitochondria, the mechanism of hexavalent chromium (Cr(VI)) hepatotoxicity, and the role of protection by GSH.
Ying Xie, Caigao Zhong, Ming Zeng, Lan Guan, Lei Luo   +4 more
doaj   +1 more source

Ethanol Consumption and Liver Mitochondria Function

Neurosignals, 2001
The mitochondrion is the subcellular organelle affected earliest during the development of alcoholic liver disease. As a result of chronic ethanol consumption mitochondrial protein synthesis is decreased significantly due to a depression in the functioning of the mitochondrial ribosome.
C C, Cunningham, S M, Bailey
openaire   +2 more sources

Lipid composition of mitochondria from bovine heart, liver, and kidney

Journal of Lipid Research, 1967
Highly purified preparations of mitochondria from bovine heart, liver, and kidney were isolated and characterized by electron microscopy, oxidative phosphorylation ability, cytochrome c reductase activity, and cytochrome content.
Sidney Fleischer, George Rouser, Becca Fleischer, Anna Casu, Gene Kritchevsky   +4 more
doaj   +1 more source

Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

Nature Communications
Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear ...
Jun Dong, Li Chen, Fei Ye, Junhui Tang, Bing Liu, Jiacheng Lin, Pang-Hu Zhou, Bin Lu, Min Wu, Jia-Hong Lu, Jing-Jing He, Simone Engelender, Qingtao Meng, Zhiyin Song, He He   +14 more
doaj   +1 more source

Oxidation of Choline in Rat Liver Mitochondria

Journal of Biological Chemistry, 1964
n ...
Giuseppe Bianchi, Giovanni Felice Azzone
openaire   +3 more sources

Selective toxicity of Caspian cobra (Naja oxiana) venom on liver cancer cell mitochondria

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To explore the cytotoxicity effects of Caspian cobra (Naja oxiana or N. oxiana) venom on hepatocytes and mitochondria obtained from the liver of HCC rats.
Enayatollah Seydi, Shabnam Babaei, Amir Fakhri, Jalal Pourahmad   +3 more
doaj   +1 more source