Results 41 to 50 of about 1,196,029 (309)
Emerging roles of mitochondria and autophagy in liver injury during sepsis [PDF]
, 2017 Recent research indicates crucial roles of autophagy during sepsis. In animal models of sepsis induced by cecal ligation and puncture (CLP) or the systemic administration of lipopolysaccharides (LPS), autophagy is implicated in the activation and/or ...
Koichi Uemura, Kana Unuma, Toshihiko Aki
core +1 more source
Research in Molecular Medicine, 2021 Background: Mitochondria are a source of reactive oxygen species (ROS), and several natural compounds are used as antioxidant agents. This study aimed to investigate and compare the effects of fresh grape juice red wine on oxidative stress biomarkers in ...
Amir Keshavarzi +5 more
doaj
Phosphatidylserine biosynthesis in mitochondria from the Morris 7777 hepatoma.
Journal of Lipid Research, 1979 Mitochondria from the 7777 hepatoma incorporate substantial amounts of l-[U-(14)C]serine into phospholipid by a Ca(2+)-dependent base-exchange reaction. This reaction is virtually absent in normal liver mitochondria.
K Y Hostetler, B D Zenner, H P Morris
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, 2020 Decades of active research have shown that mitochondrial dysfunction, the associated oxidative stress, impaired anti-stress defense mechanisms, and the activation of the proapoptotic signaling pathways underlie pathological changes in organs and tissues.
Olga Krestinina +2 more
core +1 more source
, 2023 Liver injury can result from various risk factors including diabetes, virus, alcohol, drugs, and other toxins, which is mainly responsible for global mortality and morbidity.
Deshu Kong (14641106) +7 more
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Peculiarities of the free radical processes in rat liver mitochondria under toxic hepatitis on the background of alimentary protein deficiency [PDF]
The Ukrainian Biochemical Journal, 2016 The rate of superoxide anion radical, hydroxyl radical and hydrogen peroxide generation, the level of oxidative modification of mitochondrial proteins in the liver of rats with toxic hepatitis was investigated on the background of alimentary protein ...
G. P. Kopylchuk, O. M. Voloshchuk
doaj +1 more source
The effect of arsenite on rat‐liver mitochondria [PDF]
FEBS Letters, 1971 It has been known for some time that arsenite inhibits the oxidation of 2-oxoglutarate by specifically blocking vicinal dithiols of the 2-oxoglutarate dehydrogenase complex [ 1 ] . In liver mitochondria the inhibition is maximal at about 1 mM arsenite [2] .To get complete inhibition it was earlier found essential to preincubate mitochondria with ...
openaire +2 more sources
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source