Results 11 to 20 of about 177,404 (269)
Biology, 2020 S-15176, a potent derivative of the anti-ischemic agent trimetazidine, was reported to have multiple effects on the metabolism of mitochondria. In the present work, the effect of S-15176 (1.5 mg/kg/day i.p.) on the ultrastructure and functions of liver ...
Natalia V. Belosludtseva +5 more
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Biology Direct, 2022 Background In mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrapping-type of ER that is rich in fatty acids and synthesizes lipoproteins (VLDL) (Anastasia et al.
Nicolò Ilacqua +9 more
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Role of Mitochondria in Alcoholic Liver Disease [PDF]
Current Pathobiology Reports, 2013 Alcohol-induced liver disease (ALD) is a major health concern of alcohol abuse and a leading cause of liver-related morbidity and mortality. The pathogenesis of ALD is multifactorial and still ill characterized. One of the hallmarks of ALD common for both patients and experimental models is the alteration in the architecture and function of ...
García-Ruiz, Carmen +2 more
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Detailed mitochondrial phenotyping by high resolution metabolomics. [PDF]
PLoS ONE, 2012 Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample.
James R Roede +4 more
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Mitochondrial Roles and Cytoprotection in Chronic Liver Injury
Biochemistry Research International, 2012 The liver is one of the richest organs in terms of number and density of mitochondria. Most chronic liver diseases are associated with the accumulation of damaged mitochondria.
Davide Degli Esposti +7 more
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Mitochondrial Dysfunction and Chronic Liver Disease
Current Issues in Molecular Biology, 2022 Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions,
Chunyan Zhang +5 more
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Redox Biology, 2018 Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S ...
Julia Chalker +3 more
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Contribution of mitochondria to injury of hepatocytes and liver tissue by hyperthermia
Medicina, 2017 Objective: The aim of this study was to investigate functional changes of liver mitochondria within the experimentally modeled transition zone of radiofrequency ablation and to estimate possible contribution of these changes to the energy status of liver
Rasa Žūkienė +6 more
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Frontiers in Bioengineering and Biotechnology, 2022 The mitochondrion is one of the most important cellular organelles, and many drugs work by acting on mitochondria. Curcumin (Cur)-induced apoptosis of HepG2 in liver cancer cells is closely related to the function of inhibiting mitochondria. However, the
Wanyu Li +7 more
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Journal of Mazandaran University of Medical Sciences, 2022 Background and purpose: Resveratrol (RSV) is a naturally polyphenolic compound found in grapes and other plant sources. It has potent free radical scavenger and antioxidative properties.The aim of this study was to evaluate the protective effect of ...
Maloos Naderi +3 more
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