Results 11 to 20 of about 1,196,029 (309)

Mitochondria in Chronic Liver Disease

Current Drug Targets, 2011
Mitochondria are the main energy source in hepatocytes and play a major role in extensive oxidative metabolism and normal function of the liver. This key role also assigns mitochondria a gateway function in the center of signaling pathways that mediate hepatocyte injury, because impaired mitochondrial functions affect cell survival and contribute to ...
GRATTAGLIANO I, RUSSMANN S, DIOGO CV, BONFRATE L, OLIVEIRA PJ, WANG DQ, PORTINCASA, Piero   +6 more
openaire   +4 more sources

Spermine binding to liver mitochondria

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1996
Non-equilibrium binding of spermine to mitochondrial membranes is studied in rat liver mitochondria by applying a new thermodynamic treatment of ligand-receptor interactions (Di Noto, V., Dalla Via, L., Toninello, A. and Vidali, M. (1996) Macromol. Theory Simul. 5, 165-181).
DALLA VIA, LISA, DI NOTO, VITO, DAGMAR SILIPRANDI, TONINELLO, ANTONIO   +3 more
openaire   +4 more sources

Mitochondria in Liver Diseases

, 2018
Mitochondria are not only the main energy source in the hepatocytes but also play a major role in the cell redox homeostasis and maintain normal liver function including signalling pathways and the metabolism of exogenous substances. These roles assign mitochondria a gateway function in protecting hepatocyte from injury since unbalanced mitochondrial ...
Grattagliano, Ignazio, de Bari, Ornella, Di Palo, Domenica, Montecucco, Fabrizio, Carbone, Federico, Oliveira, Paulo J., Wang, David Q. -H., Portincasa, Piero   +7 more
openaire   +3 more sources

Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases. [PDF]

, 2021
Calcium (Ca2+ ) is a second messenger essential for cellular homeostasis. Inside the cell, Ca2+ is compartmentalized and exchanged among organelles in response to both external and internal stimuli.
Pavitra Kumar, Gracia-Sancho, Jorge, Jordi Gracia‐Sancho, Chaonan Jin, Jin, Chaonan, Kumar, Pavitra, Dufour, Jean-François, Jean‐François Dufour   +7 more
core   +2 more sources

Biosynthesis of cardiolipin in liver mitochondria [PDF]

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1971
Abstract Diphosphatidylglycerol (cardiolipin) biosynthesis from CDP-diglyceride and sn-glycerol-3-phosphate has been demonstrated in a preparation of mitochondria from rat liver in a reaction requiring Mg2+. The identity of the diphosphatidylglycerol was established by thin-layer chromatography and mild alkaline hydrolysis.
Hostetler, K.Y., Bosch, H. van den, Deenen, L.L.M. van   +2 more
openaire   +3 more sources

Mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis in cirrhotic rats [PDF]

, 2020
In liver cirrhosis, oxidative stress plays a major role in promoting liver inflammation and fibrosis. Mitochondria dysregulation is responsible for excessive reactive oxygen species production.
Brocca, Alessandra, Pesce, Paola, Angeli, Paolo, Turkseven, Saadet, Bolognesi, Massimo, Di Pascoli, Marco, Turkseven S., Brocca A., Angeli P., Pesce P., Bolognesi M., Di Pascoli M.   +11 more
core   +2 more sources

Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria [PDF]

, 1967
The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
core   +1 more source

Changes of fatty acid metabolism and oxidative phosphorylation of rat liver mitochondria during 3'-Me-DAB feeding [PDF]

, 1964
Respiration, activity of oleate oxidation and composition of the total fatty acids of rat liver were investigated in 3'-Me-DAB feeding. 1. Oxidative phosphorylation of rat liver mitochondria decreased temporarily at relatively earlier stages (about 2 to ...
Inaba, Kozo
core   +1 more source

Morphology of mitochondria and cell respiration,pt.1. [PDF]

, 1960
To reveal the mechanism of liver damage by taking CCl4 the author observed the liver tissues from rats at 1.5, 5, 6, 10, 17, 20, and 22 hours after the CCl4 administration, both by light microscope and electron-microscope. 1. Light microscope observation
Haba, Kyoichi
core   +1 more source

Localization of TCA cycle dehydrogenases in the mitochondria [PDF]

, 1967
The site of localization of TCA cycle dehydrogenases in mitochondria has been investigated by observing the dehydrogenase activities and fine structure of the fractionated samples after freezing and thawing or sonication of beef heart and rat liver ...
Oda, Takuzo, Inaba, Kozo, Wakabayashi, Akira   +2 more
core   +1 more source