Results 71 to 80 of about 177,404 (269)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Impact of mitochondrial lipid alterations on liver disease mechanisms and progression
Exploration of Digestive DiseasesLipids are intricate biomolecules responsible for the building up of biological membranes. Besides this structural function, they also display crucial roles in signaling, acting as second messengers that activate specific pathways.
Laura Fàbrega +3 more
doaj +1 more source
MITOCHONDRIAL CHANGES IN THE KIDNEY AND LIVER OT MICE INDUCED BY OCHRATOXIN A - AN ELECTRONMICROSCOPIC STUDY [PDF]
Journal of Veterinary and Animal Sciences, 1994 Ultrastructural changes of renal and hepatic mitochondria in mice induced by OA were studied. Mitrochondria exhibited diverse morphological aberrations. The outer mitochondria) membranes, cristae and matrix were affected. The changes were more prominent
N. Divakaran Nair +3 more
doaj
Бюллетень сибирской медицины, 2009 The influence of hepatoprotector phospholipid nature Essentiale and Essenciale combination with succinic acid on the metabolism of liver injury caused by Paracetamol in rats has been investigated.
D. A. Korshunov
doaj +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Experimental and Molecular Medicine, 2019 Liver injury: Citrus peel to the rescue Nobiletin, an antioxidant found in citrus peel, may protect the liver from reperfusion injury, damage following blood flow interruption.
Theodomir Dusabimana +4 more
doaj +1 more source
Tissue Specific Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ Ions
Acta Medica, 2009 Ca2+-induced opening of the mitochondrial permeability transition pore (MPTP) is involved in induction of apoptotic and necrotic processes. We studied sensitivity of MPTP to calcium using the model of Ca2+-induced, cyclosporine A-sensitive mitochondrial ...
René Endlicher +5 more
doaj +1 more source
Transport and oxidation of choline by liver mitochondria [PDF]
Biochemical Journal, 1977 1. Rapid choline oxidation and the onset of Pi-induced swelling by liver mitochondria, incubated in a sucrose medium at or above pH7.0, required the addition of both Pi and an uncoupling agent. Below pH7.0, Pi alone was required for rapid choline oxidation and swelling. 2.
openaire +2 more sources
Advanced Science, EarlyView.Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source