Results 81 to 90 of about 2,143,132 (361)

C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]

, 2012
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Czerny, Christoph, Lehnert, Mark, Lemasters, John J., Maldonado, Eduardo N., Marzi, Ingo, Theruvath, Tom Prakash, Zhong, Zhi   +6 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Coming together to define membrane contact sites. [PDF]

, 2019
Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell ...
De Matteis, Maria Antonietta, Emr, Scott, Giordano, Francesca, Hajnóczky, György, Kornmann, Benoît, Lackner, Laura L., Levine, Tim P., Pellegrini, Luca, Reinisch, Karin, Rizzuto, Rosario, Schuldiner, Maya, Scorrano, Luca, Simmen, Thomas, Stenmark, Harald, Ungermann, Christian   +14 more
core   +7 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

Frontiers in Pharmacology, 2018
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe. Although significant progress has been made in understanding the molecular mechanisms underlying
Anna Moles, Anna Moles, Sandra Torres, Sandra Torres, Anna Baulies, Anna Baulies, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa   +11 more
doaj   +1 more source

Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish

Cell Death Discovery, 2021
MVP17 encodes a mitochondrial inner-membrane protein, and mutation of human MVP17 can cause mitochondria DNA depletion syndrome (MDDS). However, the underlying function of mpv17 is still elusive.
Wan-Ping Bian, Shi-Ya Pu, Shao-Lin Xie, Chao Wang, Shun Deng, Phyllis R. Strauss, De-Sheng Pei   +6 more
doaj   +1 more source

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis [PDF]

, 2010
Peer reviewedPublisher ...
A Dhanasekaran, A Dyson, A Filipovska, AL Hill, AM James, B Bedogni, BE Minter, CA Macias, CC Chuang, CE Cross, D Brealey, D Brealey, D Brealey, D Graham, DA Lowes, DA Lowes, DP Jones, E Borrelli, ED Crouser, ED Crouser, F Arnalich, FN Gellerich, G Escames, G Escames, GF Kelso, GS Supinski, H Bayir, H Bohrer, H Zhang, HC Cowley, Helen F Galley, HF Galley, HF Galley, HF Galley, HF Goode, I Spasojević, I Vanhorebeek, J Ripcke, JC Marshall, JF Turrens, JJ Pandit, JV Esplugues, K Yassen, K Zhao, KS Roser, L Packer, M Qunitero, MD Wheeler, MD Wheeler, MP Fink, MP Fink, MP Murphy, MW Fariss, P Ghafourifar, P Wipf, RAJ Smith, RAJ Smith, RL Paterson, RO Poyton, S González-Rubio, S Rinaldi, SS Sheu, V Mishra, V Vanasco, VJ Adlam, VP Skulachev, W Droge, Z Lacza   +67 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Unravelling the gut-liver axis: The role of gut microbiota-mitochondria interactions in the pathogenesis and management of metabolic-associated fatty liver disease (MAFLD)

Journal of Holistic Integrative Pharmacy
Metabolic-associated fatty liver disease (MAFLD) has emerged as a prevalent chronic liver disease. Our review of the existing literature reveals that the interplay between gut microbiota, mitochondria, and the liver is a key mechanism in the development ...
Binzhi Zhang, Xia Luo, Song Lei, Wenbo Gao, Zhipeng Chen, Qing Zhu, Lizheng Huang, Qinqiang Long   +7 more
doaj   +1 more source

Oxidative phosphorylation efficiency, proton conductance and reactive oxygen species production of liver mitochondria correlates with body mass in frogs [PDF]

, 2015
ody size is a central biological parameter affecting most biological processes (especially energetics) and mitochondria is a key organelle controlling metabolism and is also the cell's main source of chemical energy.
Dumet, A., Rey, B., Romestaing, C., Roussel, D., Salin, K., Voituron, Y.   +5 more
core   +3 more sources