Results 131 to 140 of about 1,007,169 (424)

A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production [PDF]

, 2013
A high membrane potential across the mitochondrial inner membrane leads to the production of the reactive oxygen species (ROS) implicated in aging and age-related diseases.
Affourtit, Azzu, Baron, Blaikie, Brand, Chalmers, Christensen, Cochemé, Cochemé, Dickinson, Halliwell, Harman, Hori, Horton, Lambert, Lambert, Lo, Loomis, Miwa, Murphy, Pereira, Quin, Quinlan, Quinlan, Ray, Rogers, Sareila, Sikora, Skulachev, Smith, Smith, Srikun, Tehan, Toime, Votyakova, Yuan   +35 more
core   +1 more source

Sphingolipids in mitochondria [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017
Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal transduction. In recent years, it has become apparent that sphingolipids participate in growth, senescence, differentiation and apoptosis. The anabolism and catabolism of sphingolipids occur in discrete subcellular locations and consist of a strictly ...
Lina M. Obeid, Lina M. Obeid, Mohamed Salama, Daniel Canals, María José Hernández-Corbacho, Can E. Senkal   +5 more
openaire   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

Particle and Fibre Toxicology, 2021
Background Air pollution is a complex mixture of particles and gases, yet current regulations are based on single toxicant levels failing to consider potential interactive outcomes of co-exposures.
Quincy A. Hathaway, Nairrita Majumder, William T. Goldsmith, Amina Kunovac, Mark V. Pinti, Jack R. Harkema, Vince Castranova, John M. Hollander, Salik Hussain   +8 more
doaj   +1 more source

Tensile Forces and Shape Entropy Explain Observed Crista Structure in Mitochondria [PDF]

, 2010
A model is presented from which the observed morphology of the inner mitochondrial membrane can be inferred as minimizing the system's free energy. Besides the usual energetic terms for bending, surface area, and pressure difference, our free energy includes terms for tension that we believe to be exerted by proteins and for an entropic contribution ...
arxiv   +1 more source

HIVE-Net: Centerline-Aware HIerarchical View-Ensemble Convolutional Network for Mitochondria Segmentation in EM Images [PDF]

arXiv, 2021
Semantic segmentation of electron microscopy (EM) is an essential step to efficiently obtain reliable morphological statistics. Despite the great success achieved using deep convolutional neural networks (CNNs), they still produce coarse segmentations with lots of discontinuities and false positives for mitochondria segmentation.
arxiv  

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria [PDF]

, 2014
Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
A Filippini, A Golks, AV Nikonov, C Cerqua, C Frezza, C Giampietri, C Giampietri, C Giorgi, C Scaffidi, D Chandra, D Ferrari, DG Breckenridge, DG Breckenridge, E Area-Gomez, E S Marini, E Zampese, E Ziparo, EM Manders, F Gonzalvez, FW Ng, G Grynkiewicz, G Orso, GK Voeltz, I Sparkes, J Hu, J Zhang, JE Vance, JR Friedman, KH Shain, L Jozsef, L Scorrano, M Irmler, M Li, MJ Dayel, N Myhill, N Wittkopf, OM de Brito, OM de Brito, R Katayama, R Rizzuto, R Rizzuto, R Schweigreiter, R Xiang, RS Misra, S Conti, S Petrungaro, SH Park, T Simmen, TW Day, WC Yeh, Y Shibata, Y Shibata, Y Shibata, ZT Schug   +53 more
core   +2 more sources

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

Diabetes, 2002
Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because the insulin resistance of skeletal muscle in type 2 diabetes and obesity entails dysregulation of the oxidation of both carbohydrate and lipid fuels, the ...
D. Kelley, Jing He, Elizabeth V. Menshikova, V. Ritov   +3 more
semanticscholar   +1 more source

Mitochondria and arrhythmias

Free Radical Biology and Medicine, 2014
Mitochondria are essential to providing ATP, thereby satisfying the energy demand of the incessant electrical activity and contractile action of cardiac muscle. Emerging evidence indicates that mitochondrial dysfunction can adversely affect cardiac electrical functioning by impairing the intracellular ion homeostasis and membrane excitability through ...
Marcelo G. Bonini, Samuel C. Dudley, Kai-Chien Yang   +2 more
openaire   +4 more sources

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source