Results 251 to 260 of about 851,372 (311)

STIM1-Mitofusin2 interactions tether mitochondria and melanosome contacts that promote melanosome maturation. [PDF]

Nat Commun
Shiiba I, Ishikawa Y, Oshio H, Ito N, Yamaguchi F, Nagashima S, Ando H, Umezawa K, Miura Y, Araiso Y, Nakamura K, Hirabayashi Y, Inatome R, Yanagi S.   +13 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies. [PDF]

Front Pharmacol
Chen Y, Li H, He W.
europepmc   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Diffusive spreading across dynamic mitochondrial network architectures. [PDF]

Proc Natl Acad Sci U S A
Holt KB, Zurita C, Teryoshin L, Lewis SC, Koslover EF.   +4 more
europepmc   +1 more source

Decoding Drug Resistance in Pancreatic Cancer: A Subcellular Structure Perspective. [PDF]

Biology (Basel)
Li X, Lyu H, Wu Y, Chen A, Wu G, Zhang R, Xiao S, Guo D, Zhang Q, Yan C, Tang J, Zhou C.   +11 more
europepmc   +1 more source

Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk. [PDF]

Cell Death Dis
Amieghemen CI, Ung TT, Huskin GN, Mobley JA, Chimento MF, Nguyen M, Fortenberry J, Kraft TW, Pittler SJ, Wang Y.   +9 more
europepmc   +1 more source

E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model. [PDF]

J Neurochem
Wang Y, Zhu J, Lizarazo S, Lee KY, Wong O, Azim S, Yook Y, Kumar V, Tsai NP.   +8 more
europepmc   +1 more source

From the energy factory to the intercellular communication medium: the emerging role of intercellular mitochondrial transfer and mitochondrial transplantation therapy in diabetes and diabetic complications. [PDF]

J Transl Med
Li D, Liu X, Zhang L, Gong Q, Huang W, Xu Y.   +5 more
europepmc   +1 more source