Results 41 to 50 of about 1,199,861 (319)

Adaptation of mitochondrial bioenergetics to coenzyme Q deficiency in human endothelial cells after chronic exposure to bisphosphonates

Scientific Reports
Nitrogen-containing bisphosphonates (N-BPs), widely used in bone disease therapy, inhibit the mevalonate pathway, which affects coenzyme Q (CoQ) biosynthesis and may compromise mitochondrial function, particularly in endothelial cells where oxidative ...
Adrianna Budzinska, Lukasz Galganski, Krzysztof Wojcicki, Wieslawa Jarmuszkiewicz   +3 more
doaj   +1 more source

Morphological Pathways of Mitochondrial Division

Antioxidants, 2018
Mitochondrial fission is essential for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation.
Bernard Tandler, Charles L. Hoppel, Jason A. Mears   +2 more
doaj   +1 more source

Mitochondrial DNA mutations in ageing and cancer

Molecular Oncology, 2022
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70.
Anna L. M. Smith, Julia C. Whitehall, Laura C. Greaves   +2 more
doaj   +1 more source

Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice

Frontiers in Cell and Developmental Biology, 2021
Noise exposure of a short period at a moderate level can produce permanent cochlear synaptopathy without seeing lasting changes in audiometric threshold.
Hongchao Liu, Hongchao Liu, Hongchao Liu, Hu Peng, Longhao Wang, Longhao Wang, Longhao Wang, Pengcheng Xu, Pengcheng Xu, Pengcheng Xu, Zhaoyan Wang, Zhaoyan Wang, Zhaoyan Wang, Huihui Liu, Huihui Liu, Huihui Liu, Hao Wu, Hao Wu, Hao Wu   +18 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Early steps in mitochondrial protein import [PDF]

, 1990
The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Stuart, Rosemary A., Neupert, Walter, Nicholson, Donald W.   +2 more
core   +1 more source

Mitochondrial Membrane Remodeling [PDF]

, 2022
Mitochondria are key regulators of many important cellular processes and their dysfunction has been implicated in a large number of human disorders.
Yang, Cheng, Wu, Qiong, Zhou, Zuping, Guo, Ziqi, Yang, Ziyun, Pu, Shiming, Wang, Liang, Zhao, Hongxia   +7 more
core   +1 more source

The bisphosphonates alendronate and zoledronate induce adaptations of aerobic metabolism in permanent human endothelial cells

Scientific Reports, 2023
Nitrogen-containing bisphosphonates (NBPs), compounds that are widely used in the treatment of bone disorders, may cause side effects related to endothelial dysfunction. The aim of our study was to investigate the effects of chronic 6-day exposure to two
Adrianna Budzinska, Lukasz Galganski, Wieslawa Jarmuszkiewicz   +2 more
doaj   +1 more source

BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases

Frontiers in Endocrinology, 2023
Subcellular organelles dysfunction is implicated in various diseases, including metabolic diseases, neurodegenerative diseases, cancer, and cardiovascular diseases.
Guoji Xiong, Guoji Xiong, Kexin Zhang, Kexin Zhang, Yujie Ma, Yixin Song, Yixin Song, Wenqiang Zhang, Wenqiang Zhang, Wenqiang Zhang, Tongbing Qi, Tongbing Qi, Hongyan Qiu, Hongyan Qiu, Junfeng Shi, Junfeng Shi, Chengxia Kan, Chengxia Kan, Jingwen Zhang, Jingwen Zhang, Xiaodong Sun, Xiaodong Sun   +21 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source