Results 31 to 40 of about 1,199,861 (319)

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
W Neupert, Herrmann, Johannes M., Stuart, Rosemary A., Neupert, Walter, J M Herrmann, Craig, Elisabeth A., E A Craig, R A Stuart   +7 more
core   +1 more source

mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease

EMBO Molecular Medicine, 2018
Mitochondrial disease associated with the pathogenic m.3243A>G variant is a common, clinically heterogeneous, neurogenetic disorder. Using multiple linear regression and linear mixed modelling, we evaluated which commonly assayed tissue (blood N = 231 ...
John P Grady, Sarah J Pickett, Yi Shiau Ng, Charlotte L Alston, Emma L Blakely, Steven A Hardy, Catherine L Feeney, Alexandra A Bright, Andrew M Schaefer, Gráinne S Gorman, Richard JQ McNally, Robert W Taylor, Doug M Turnbull, Robert McFarland   +13 more
doaj   +1 more source

Mitochondrial helicases and mitochondrial genome maintenance [PDF]

Mechanisms of Ageing and Development, 2010
Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of ...
de Souza-Pinto, Nadja C, Aamann, Maria Diget, Kulikowicz, Tomasz, Stevnsner, Tinna V., Bohr, Vilhelm A   +4 more
openaire   +3 more sources

Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution [PDF]

, 2012
Only a few genes remain in the mitochondrial genome retained by every eukaryotic organism that carry out essential functions and are implicated in severe diseases.
Steinmetz⁎, L.M., Tetaud, Emmanuel, Steinmetz, Lars M, Annie Sainsard-Chanet, Giraud, Marie-France, Roza Kucharczyk (141980), Bietenhader, M., Raeka S Aiyar, Martos, Alexandre, Steinmetz, Lars M., Lars M Steinmetz, Sandra Clauder-Münster, Denmat, S. Hermann-Le, Dequard-Chablat, Michelle, Sylvie Hermann-Le Denmat (30181), Giraud, M.-F., Gagneur, Julien, Denmat, Sylvie Hermann-Le, Aiyar, Raeka, S, Maïlis Bietenhader, Emmanuel Tetaud (40495), Déquard-Chablat, M., Roza Kucharczyk, Martos, A., Annie Sainsard-Chanet (141993), Aiyar, R.S., Sainsard-Chanet, Annie, Isabelle Sagot, di Rago⁎, J.-P., Julien Gagneur (4350), Jean-Paul di Rago, Gagneur, J., Kucharczyk, R., Clauder-Münster, S., Jean-Paul di Rago (118317), Marie-France Giraud, Raeka S. Aiyar (141976), Godard, François, Bénédicte Salin (48466), di Rago, Jean-Paul, Carole H Sellem, Emmanuel Tetaud, Salin, Bénédicte, Godard, F., Steinmetz, Lars, M, Godard, Franc¸ois, Hermann-Le Denmat, Sylvie, Sylvie Hermann-Le Denmat, François Godard (14571), Sellem, Carole, H, Tetaud, E., Lars M. Steinmetz (36847), Véronique Contamine, Sagot, I., Alexandre Martos (141974), Contamine, V., Bénédicte Salin, Sainsard-Chanet, A., Marie-France Giraud (141983), Maïlis Bietenhader (141972), Clauder-Münster, Sandra, Sandra Clauder-Münster (141982), Isabelle Sagot (48468), François Godard, Sagot, Isabelle, Michelle Déquard-Chablat (141986), Michelle Déquard-Chablat, Julien Gagneur, Salin, B., Sellem, Carole H, Contamine, Veronique, Bietenhader, Mailis, Kucharczyk, Roza, Aiyar, Raeka S, Carole H. Sellem (141978), Véronique Contamine (141989), Alexandre Martos, Sellem, C.H.   +77 more
core   +1 more source

Transport of proteins across mitochondrial membranes [PDF]

, 1994
The vast majority of proteins comprising the mitochondrion are encoded by nuclear genes, synthesized on ribosomes in the cytosol, and translocated into the various mitochondrial subcompartments. During this process proteins must cross the lipid membranes
Neupert, Walter
core   +1 more source

Mitochondrial dynamics: quantifying mitochondrial fusion in vitro [PDF]

BMC Biology, 2010
Mitochondrial fusion is an essential process for preserving the integrity and stability of mitochondrial DNA; however, regulation of this process remains largely mysterious. In this issue of BMC Biology, Schauss and colleagues describe a simple, reliable, and robust novel assay that allows fusion of mammalian mitochondria to be quantified in vitro.
Jourdain Alexis, Martinou Jean-Claude
openaire   +6 more sources

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

Cell Reports, 2015
Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. Although aging and fasting alter many redox processes, the role of cysteine residues is uncertain.
Katja E. Menger, Andrew M. James, Helena M. Cochemé, Michael E. Harbour, Edward T. Chouchani, Shujing Ding, Ian M. Fearnley, Linda Partridge, Michael P. Murphy   +8 more
doaj   +1 more source

Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins

npj Parkinson's Disease, 2023
Mitochondrial dysfunction has been suggested to contribute to Parkinson’s disease pathogenesis, though an understanding of the extent or exact mechanism of this contribution remains elusive.
Chun Chen, David McDonald, Alasdair Blain, Emily Mossman, Kiera Atkin, Michael F. Marusich, Roderick Capaldi, Laura Bone, Anna Smith, Andrew Filby, Daniel Erskine, Oliver Russell, Gavin Hudson, Amy E. Vincent, Amy K. Reeve   +14 more
doaj   +1 more source

Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes

Redox Biology, 2020
Mutations in mitochondrial DNA can be inherited or occur de novo leading to several debilitating myopathies with no curative option and few or no effective treatments.
Caitlin J. Lewis, Bhavna Dixit, Elizabeth Batiuk, Carter J. Hall, Matthew S. O'Connor, Amutha Boominathan   +5 more
doaj   +1 more source

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Pfanner, Nikolaus, Tropschug, Maximilian, Neupert, Walter   +2 more
core   +1 more source