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Mitochondrial diseases [PDF]

Nature Reviews Disease Primers, 2016
Mitochondrial diseases are a group of genetic disorders that are characterized by defects in oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) that encode structural mitochondrial proteins or proteins involved in mitochondrial function.
Gorman G. S., Chinnery P. F., DiMauro S., Hirano M., Koga Y., McFarland R., Suomalainen A., Thorburn D. R., Zeviani M., Turnbull D. M.   +9 more
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Navigating Life With Primary Mitochondrial Myopathies: The Importance of the Patient Voice and Implications for Clinical Practice

Journal of Primary Care & Community Health, 2023
Primary mitochondrial myopathies (PMM) are rare disorders with diverse and progressive symptom presentations that cause a substantial, detrimental impact on the quality of life of patients and their caregivers.
Margaret Moore, Philip Yeske, Sumit Parikh   +2 more
doaj   +1 more source

Correction to: Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence

Translational Psychiatry, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01239 ...
Roel J. T. Mocking, Jane C. Naviaux, Kefeng Li, Lin Wang, Jonathan M. Monk, A. Taylor Bright, Caroline A. Figueroa, Aart H. Schene, Henricus G. Ruhé, Johanna Assies, Robert K. Naviaux   +10 more
doaj   +1 more source

Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence

Translational Psychiatry, 2021
Recurrent major depressive disorder (rMDD) is a relapsing-remitting disease with high morbidity and a 5-year risk of recurrence of up to 80%. This was a prospective pilot study to examine the potential diagnostic and prognostic value of targeted plasma ...
Roel J. T. Mocking, Jane C. Naviaux, Kefeng Li, Lin Wang, Jonathan M. Monk, A. Taylor Bright, Caroline A. Figueroa, Aart H. Schene, Henricus G. Ruhé, Johanna Assies, Robert K. Naviaux   +10 more
doaj   +1 more source

Metabolic features of treatment-refractory major depressive disorder with suicidal ideation

Translational Psychiatry, 2023
Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal ideation, and to identify individualized differences for personalized care.
Lisa A. Pan, Jane C. Naviaux, Lin Wang, Kefeng Li, Jonathan M. Monk, Sai Sachin Lingampelly, Anna Maria Segreti, Kaitlyn Bloom, Jerry Vockley, Mark A. Tarnopolsky, David N. Finegold, David G. Peters, Robert K. Naviaux   +12 more
doaj   +1 more source

Improved Dried Blood Spot-Based Metabolomics: A Targeted, Broad-Spectrum, Single-Injection Method

Metabolites, 2020
Dried blood spots (DBS) have proven to be a powerful sampling and storage method for newborn screening and many other applications. However, DBS methods have not yet been optimized for broad-spectrum targeted metabolomic analysis.
Kefeng Li, Jane C. Naviaux, Jonathan M. Monk, Lin Wang, Robert K. Naviaux   +4 more
doaj   +1 more source

Development and evaluation of a novel chromium III-based compound for potential inhibition of emerging SARS-CoV-2 variants

Heliyon, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused 403 million cases of coronavirus disease (COVID-19) and resulted in more than 5.7 million deaths worldwide.
Yu-Jung Lin, Navaneethan Sundhar, Hema Sri Devi, Hsueh-Fa Pien, Shina Fong-Mei Wen, Jenn-Line Sheu, Bruce Chi-Kang Tsai, Chih-Yang Huang   +7 more
doaj   +1 more source

Morphological Pathways of Mitochondrial Division

Antioxidants, 2018
Mitochondrial fission is essential for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation.
Bernard Tandler, Charles L. Hoppel, Jason A. Mears   +2 more
doaj   +1 more source

Rescue of Heart Failure by Mitochondrial Recovery [PDF]

International Neurourology Journal, 2016
Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further ...
Jubert Marquez, Sung Ryul Lee, Nari Kim, Jin Han   +3 more
doaj   +1 more source

Exercise and Neuroinflammation in Health and Disease [PDF]

International Neurourology Journal, 2019
Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Dae-Yun Seo, Jun-Won Heo, Jeong Rim Ko, Hyo-Bum Kwak   +3 more
doaj   +1 more source