Results 251 to 260 of about 543,462 (281)

Clinical features and treatment of stroke-like episodes in mitochondrial disease: a cohort-based study. [PDF]

J Neurol
Mickelsson N, Hirvonen J, Martikainen MH.   +2 more
europepmc   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation.

Cell Rep
Bordi M, Testa B, Compagnucci C, Colasuonno F, Cipressa F, Betterini E, Mancini A, Carsetti C, Salvatori I, Ferraina C, Yang M, De Cegli R, Del Prete E, Veroni C, Rizza S, Mauri S, Ziviani E, Macchiaiolo M, Vecchio D, Panfili FM, Rizza T, Weber G, Carrozzo R, Ferri A, Campello S, Ballabio A, Frezza C, Cestra G, Tartaglia M, Bartuli A, Cecconi F.   +30 more
europepmc   +1 more source

Quantitative proteomics of patient fibroblasts reveal biomarkers and diagnostic signatures of mitochondrial disease. [PDF]

JCI Insight
Correia SP, Moedas MF, Taylor LS, Naess K, Lim AZ, McFarland R, Kazior Z, Rumyantseva A, Wibom R, Engvall M, Bruhn H, Lesko N, Végvári Á, Käll L, Trost M, Alston CL, Freyer C, Taylor RW, Wedell A, Wredenberg A.   +19 more
europepmc   +1 more source

Pregnancy in women with mitochondrial disease-A literature review and suggested guidance for preconception and pregnancy care. [PDF]

Aust N Z J Obstet Gynaecol
Hui L, Hayman P, Buckland A, Fahey MC, Mackey DA, Mallett AJ, Schweitzer DR, Stuart CP, Yau WY, Christodoulou J.   +9 more
europepmc   +1 more source

Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics

Marissa D. Pokharel, Alejandro Garcia Flores, David Marciano, María Clara Franco, Jeffrey R. Fineman, Saurabh Aggarwal, Ting Wang, Stephen M. Black   +7 more
openalex   +1 more source

Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease. [PDF]

EMBO Mol Med
Van Haute L, Páleníková P, Tang JX, Nash PA, Simon MT, Pyle A, Oláhová M, Powell CA, Rebelo-Guiomar P, Stover A, Champion M, Deshpande C, Baple EL, Stals KL, Ellard S, Anselem O, Molac C, Petrilli G, Loeuillet L, Grotto S, Attie-Bitach T, Abdenur JE, Taylor RW, Minczuk M.   +23 more
europepmc   +1 more source

Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α. [PDF]

J Clin Invest
Wang H, Miranda M, Marutani E, Lichtenegger P, Wojtkiewicz GR, Ichinose F, Mootha VK.   +6 more
europepmc   +1 more source

Unilateral Hearing Loss and Auditory Asymmetry in Mitochondrial Disease: A Scoping Review. [PDF]

J Clin Med
Manuelli M, Migliorelli A, Bianchini C, Stomeo F, Pelucchi S, Genovese E, Monzani D, Palma S, Ciorba A.   +8 more
europepmc   +1 more source

Prenatal and progressive coenzyme Q₁₀ administration to mitigate muscle dysfunction in mitochondrial disease. [PDF]

J Cachexia Sarcopenia Muscle
Hernández-Camacho JD, Vicente-García C, Ardila-García L, Padilla-Campos A, López-Lluch G, Santos-Ocaña C, Zammit PS, Carvajal JJ, Navas P, Fernández-Ayala DJM.   +9 more
europepmc   +1 more source