Results 51 to 60 of about 9,815,793 (361)

A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

Marine Drugs, 2018
Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Hyoung Kyu Kim, Sung Woo Cho, Hye Jin Heo, Seung Hun Jeong, Min Kim, Kyung Soo Ko, Byoung Doo Rhee, Natalia P. Mishchenko, Elena A. Vasileva, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +11 more
doaj   +1 more source

Mitochondrial calcium uptake 1 (MICU1) gene-related myopathy with extrapyramidal signs: A clinico-radiological case report from India

Annals of Indian Academy of Neurology, 2023
Myopathy with extrapyramidal signs (MPXPS) is a rarely reported entity worldwide, manifesting as a muscular dystrophy with movement disorders. It results from mutations in the mitochondrial calcium uptake 1 (MICU1) gene.
Debaleena Mukherjee, Adreesh Mukherjee, Subhadeep Gupta, Souvik Dubey, Alak Pandit   +4 more
doaj   +1 more source

Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response

Biology, 2019
The rate of biological aging varies cyclically and episodically in response to changing environmental conditions and the developmentally-controlled biological systems that sense and respond to those changes.
Robert K. Naviaux
doaj   +1 more source

Aberrant neurovascular coupling in Leber’s hereditary optic neuropathy: Evidence from a multi-model MRI analysis

Frontiers in Neuroscience, 2023
The study aimed to investigate the neurovascular coupling abnormalities in Leber’s hereditary optic neuropathy (LHON) and their associations with clinical manifestations.
Yi Ji, Ling Wang, Hao Ding, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin   +8 more
doaj   +1 more source

mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease

EMBO Molecular Medicine, 2018
Mitochondrial disease associated with the pathogenic m.3243A>G variant is a common, clinically heterogeneous, neurogenetic disorder. Using multiple linear regression and linear mixed modelling, we evaluated which commonly assayed tissue (blood N = 231 ...
J. Grady, S. Pickett, Y. Ng, C. Alston, E. Blakely, S. Hardy, C. Feeney, A. Bright, A. Schaefer, G. Gorman, R. McNally, Robert W. Taylor, D. Turnbull, R. Mcfarland   +13 more
semanticscholar   +1 more source

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

Cell Death and Disease, 2022
Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and apoptosis.
Anqi Li, Meng Gao, Bili Liu, Yuan Qin, Lei Chen, Hanyu Liu, Huayan Wu, Guohua Gong   +7 more
semanticscholar   +1 more source

Development and evaluation of a novel chromium III-based compound for potential inhibition of emerging SARS-CoV-2 variants

Heliyon, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused 403 million cases of coronavirus disease (COVID-19) and resulted in more than 5.7 million deaths worldwide.
Yu-Jung Lin, Navaneethan Sundhar, Hema Sri Devi, Hsueh-Fa Pien, Shina Fong-Mei Wen, Jenn-Line Sheu, Bruce Chi-Kang Tsai, Chih-Yang Huang   +7 more
doaj  

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

PLoS ONE, 2019
Background Mitochondrial disease is a family of genetic disorders characterized by defects in the generation and regulation of energy. Epilepsy is a common symptom of mitochondrial disease, and in the vast majority of cases, refractory to commonly used ...
Amanda H. Kahn-Kirby, Akiko Amagata, Celine I. Maeder, J. J. Mei, S. Sideris, Y. Kosaka, Andrew Hinman, Stephanie A. Malone, Joel J. Bruegger, Leslie Wang, Virna Kim, W. Shrader, K. G. Hoff, Joey C. Latham, E. Ashley, M. Wheeler, E. Bertini, R. Carrozzo, D. Martinelli, C. Dionisi-Vici, K. Chapman, G. Enns, W. Gahl, L. Wolfe, R. Saneto, Simon C. Johnson, J. Trimmer, M. Klein, Charles R. Holst   +28 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease

Cells, 2019
Dysfunction of mitochondria causes defects in oxidative phosphorylation system (OXPHOS) and increased production of reactive oxygen species (ROS) triggering the activation of the cell death pathway that underlies the pathogenesis of aging and various ...
D. Lin, Yu‐Wen Huang, Che-Sheng Ho, Pi-Lien Hung, M. Hsu, Tuan-Jen Wang, Tsu‐Yen Wu, Tsung-Han Lee, Zongguang Huang, Po-Chun Chang, M. Chiang   +10 more
semanticscholar   +1 more source