Results 31 to 40 of about 160,746 (308)

Mitochondrial agents for bipolar disorder [PDF]

, 2018
BACKGROUND: Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery.
Pereira, C, Berk, M, Chavarria, V, Vian, J, Marx, W, Ashton, MM, Dean, OM   +6 more
core   +2 more sources

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration [PDF]

, 2009
Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive ...
Rüb Udo, Jendrach, M., Wenzel, Dirk, Auburger Georg, Miguel Barrera, Nussbaum, Robert L, Leuner, K., Hoepken, Hans Hermann, Amy Chen, Kudin, Alexei P, Auburger, Georg, Mekhman Azizov, Zimmermann, Annabelle, Zimmerman, Annabelle, Fernández-Ruiz, Javier, Dorothea Becker, Nussbaum, R., Becker, D., Auburger, G., Gispert, Suzana, Zimmermann Annabelle, Hoepken, Hans-Hermann, Nussbaum, Robert L., Robert L Nussbaum, Hoepken, H., Müller Walter E., Leslie Huber, Müller, Walter E., Gispert Suzana, García-Arencíbia, Moisés, Roeper Jochen, Ricciardi Filomena, Jendrach Marina, Dirk Wenzel, Kurz, A., Kurz Alexander, Voos, W., Azizov Mekhman, Kunz Wolfram S., Kurz, Alexander, Jendrach, Marina, Jochen Roeper, Müller, W., Wenzel, D., Rohrer, Hermann, Gispert, S., Hoepken Hans-Hermann, Azizov, M., Andreas S Reichert, Udo Rüb, Voos, Wolfgang, Reichert, Andreas S., Kristina Leuner, Rohrer, H., Kunz, Wolfram S, Javier Fernández-Ruiz, Barrera Miguel, Rüb, Udo, Wenzel Dirk, Chen Amy, Becker Dorothea, Rüb, U., Marina Jendrach, Müller, Walter E, Chen, A., Barrera, Miguel, Moisés García-Arencíbia, Fernández-Ruiz Javier, Wolfram S Kunz, Kudin, Alexei P., Reichert, A., Annabelle Zimmermann, Fernández-Ruiz, J., Kunz, W., Leuner Kristina, Rohrer Hermann, Alexander Kurz, Reichert Andreas S., Alexei P Kudin, Hermann Rohrer, Azizov, Mekhman, Reichert, Andreas, Zimmermann, A., Walter E Müller, Barrera, M., García-Arencíbia Moisés, Nussbaum Robert L., Roeper, Jochen, Chen, Amy, Filomena Ricciardi, Hans-Hermann Hoepken, Kudin Alexei P., Huber, L., Suzana Gispert, García-Arencíbia, M., Becker, Dorothea, Reichert, Andreas S, Georg Auburger, Huber Leslie, Ricciardi, Filomena, Ricciardi, F., Kunz, Wolfram S., Kudin, A., Leuner, Kristina, Roeper, J., Wolfgang Voos, Voos Wolfgang, Huber, Leslie   +107 more
core   +1 more source

Epilepsy in mitochondrial disorders [PDF]

Seizure, 2012
Information about epilepsy in mitochondrial disorders is scarce although a number or syndromic and non-syndromic mitochondrial disorders frequently manifest with focal or generalized seizures. Aim of the review was to describe epilepsy in syndromic and non-syndromic mitochondrial disorders with epilepsy as a dominant or collateral feature of the ...
Finsterer, Josef, Zarrouk Mahjoub, Sinda
openaire   +2 more sources

The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity [PDF]

, 2009
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors ...
Achilli Alessandro, GHELLI, ANNA MARIA, Mattioli Stefano, Pala M., Barbieri, Anna, Vidoni S., Torroni Antonio, Carelli Valerio, Anna Barbieri, Vidoni, Sara, Valerio Carelli, Carelli, Valerio, Ghelli, Anna, Mattioli, Stefano, Torroni, Antonio, Iommarini, Luisa, Zanna, Claudia, Pala, Maria, Vidoni Sara, Stefano Mattioli, Antonio Torroni, Achilli A., ZANNA C, Porcelli Anna Maria, Zanna Claudia, Pala Maria, MATTIOLI S, Luisa Iommarini, GHELLI A, Achilli, Alessandro, IOMMARINI L, Rugolo, Michela, Torroni A., Porcelli, Anna Maria, CARELLI V., Ghelli Anna, Rugolo Michela, BARBIERI A, RUGOLO M, PORCELLI AM, Anna Ghelli, Barbieri Anna, Sara Vidoni, Maria Pala, Alessandro Achilli, Anna Maria Porcelli, Michela Rugolo, Claudia Zanna, Iommarini Luisa, VIDONI S   +49 more
core   +1 more source

Metabolic effects of bezafibrate in mitochondrial disease

EMBO Molecular Medicine, 2020
Mitochondrial disorders affect 1/5,000 and have no cure. Inducing mitochondrial biogenesis with bezafibrate improves mitochondrial function in animal models, but there are no comparable human studies. We performed an open‐label observational experimental
Hannah Steele, Aurora Gomez‐Duran, Angela Pyle, Sila Hopton, Jane Newman, Renae J Stefanetti, Sarah J Charman, Jehill D Parikh, Langping He, Carlo Viscomi, Djordje G Jakovljevic, Kieren G Hollingsworth, Alan J Robinson, Robert W Taylor, Leonardo Bottolo, Rita Horvath, Patrick F Chinnery   +16 more
doaj   +1 more source

Metabolic consequences of neuronal mitochondrial fission ablation [PDF]

, 2016
Dynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality.
Restelli, Lisa Michelle
core   +1 more source

Analyzing the Potential Biological Determinants of Autism Spectrum Disorder: From Neuroinflammation to the Kynurenine Pathway

Brain Sciences, 2020
Autism Spectrum Disorder (ASD) etiopathogenesis is still unclear and no effective preventive and treatment measures have been identified. Research has focused on the potential role of neuroinflammation and the Kynurenine pathway; here we review the ...
Rosa Savino, Marco Carotenuto, Anna Nunzia Polito, Sofia Di Noia, Marzia Albenzio, Alessia Scarinci, Antonio Ambrosi, Francesco Sessa, Nicola Tartaglia, Giovanni Messina   +9 more
doaj   +1 more source

Mitochondrial disorders and the eye [PDF]

Eye and Brain, 2011
The clinical significance of disturbed mitochondrial function in the eye has emerged since mitochondrial DNA (mtDNA) mutation was described in Leber's hereditary optic neuropathy. The spectrum of mitochondrial dysfunction has become apparent through increased understanding of the contribution of nuclear and somatic mtDNA mutations to mitochondrial ...
Nicole J, Van Bergen, Rahul, Chakrabarti, Evelyn C, O'Neill, Jonathan G, Crowston, Ian A, Trounce   +4 more
openaire   +5 more sources

Expansion of the clinical and neuroimaging spectrum associated with NDUFS8‐related disorder

JIMD Reports, 2022
Biallelic pathogenic variants in NDUFS8, a nuclear gene encoding a subunit of mitochondrial complex I, result in a mitochondrial disorder characterized by varying clinical presentations and severity. Here, we expand the neuroimaging and clinical spectrum
Milena M. Andzelm, Shanti Balasubramaniam, Edward Yang, Alison G. Compton, Kate Millington, Jia Zhu, Irina Anselm, Lance H. Rodan, David R. Thorburn, John Christodoulou, Siddharth Srivastava   +10 more
doaj   +1 more source

Treatment of Mitochondrial Disorders [PDF]

Current Treatment Options in Neurology, 2014
While numerous treatments for mitochondrial disorders have been suggested, relatively few have undergone controlled clinical trials. Treatment of these disorders is challenging, as only symptomatic therapy is available. In this review we will focus on newer drugs and treatment trials in mitochondrial diseases, with a special focus on medications to ...
Sreenivas, Avula, Sumit, Parikh, Scott, Demarest, Jonathan, Kurz, Andrea, Gropman   +4 more
openaire   +2 more sources