Results 31 to 40 of about 3,268,780 (386)
DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction
Journal of Advanced Research, 2022 Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou +11 more
doaj +1 more source
Journal of Clinical Investigation, 2020 Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an endogenous free radical scavenger synthesized by neuronal mitochondria, decreases with aging and ...
A. Jauhari +12 more
semanticscholar +1 more source
Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]
, 2019 Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni +6 more
core +2 more sources
A rapid and efficient method for enriching mitochondrial DNA from plants
Mitochondrial DNA. Part B. Resources, 2018 Current mitochondrial purification techniques are tedious and protracted due to their emphasis on recovering physiologically active mitochondria. However, for studies that are exclusively interested in isolating mitochondrial DNA (mtDNA) for applications
Mackenzie M. Strehle +2 more
doaj +1 more source
Cells, 2022 Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak +2 more
doaj +1 more source
The rise and rise of mitochondrial DNA mutations
Open Biology, 2020 How mitochondrial DNA mutations clonally expand in an individual cell is a question that has perplexed mitochondrial biologists for decades. A growing body of literature indicates that mitochondrial DNA mutations play a major role in ageing, metabolic ...
C. Lawless +4 more
semanticscholar +1 more source
Spermatozoon and mitochondrial DNA [PDF]
Reproductive Medicine and Biology, 2002 In eukaryotic cells, mitochondria are the major site of ATP production, which is achieved through the electron‐transport chain and oxidative phosphorylation, according to the energy demand. Mitochondria contain their own genome (mitochondrial DNA, mtDNA) on which a limited number of genes are encoded. In the human sperm, mitochondria helically wrap the
Shuji Hirata +3 more
openaire +3 more sources
A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]
, 2018 BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin +7 more
core +1 more source
Extensive Structural Variations Between Mitochondrial Genomes of CMS and Normal Peppers (Capsicum Annuum L.) Revealed by Complete Nucleotide Sequencing [PDF]
, 2014 Cytoplasmic male sterility (CMS) is an inability to produce functional pollen that is caused by mutation of the mitochondrial genome. Comparative analyses of mitochondrial genomes of lines with and without CMS in several species have revealed structural ...
Choi, Yoomi +4 more
core +2 more sources
Determination of Mitochondrial DNA Upon Drug Treatment
Bio-Protocol, 2015 Drug-induced mitochondrial injury can be caused by many different mechanisms including inhibition of mitochondrial DNA replication, transcription, translation, and altered protein function.
Michel Perron, Joy Feng
doaj +1 more source