Results 51 to 60 of about 613,759 (317)

Commentary of "The Use of Mitochondrial Replacement in IVF: A Call for Expansion"

Voices in Bioethics, 2014
by Lillian Ringel • Briana’s op-ed calling for expansion of mitochondrial DNA replacement in IVF was an interesting read.  She starts her op-ed with a description of what mitochondrial DNA is, and though it may seem rudimentary to some, since I have a
Lillian Ringel, Amy Scharf
doaj   +1 more source

TYMP Variants Result in Late-Onset Mitochondrial Myopathy With Altered Muscle Mitochondrial DNA Homeostasis

Frontiers in Genetics, 2020
Biallelic TYMP variants result in the mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a juvenile-onset disorder with progressive course and fatal outcome. Milder late-onset (>40 years) form has been rarely described.
Dario Ronchi, Dario Ronchi, Leonardo Caporali, Giulia Francesca Manenti, Megi Meneri, Susan Mohamed, Andreina Bordoni, Francesca Tagliavini, Manuela Contin, Manuela Contin, Daniela Piga, Monica Sciacco, Cristina Saetti, Cristina Saetti, Valerio Carelli, Valerio Carelli, Giacomo Pietro Comi, Giacomo Pietro Comi   +17 more
doaj   +1 more source

Immunological evaluation of patients with Alzheimer's disease based on mitogen-stimulated cytokine productions and mitochondrial DNA indicators

BMC Psychiatry, 2023
Background Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease.
Jiewen Huang, Zhen Song, Beiwen Wei, Qingtian Li, Ping Lin, Hui Li, Ke Dong   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MITOCHONDRIAL DNA POLYMORPHISMS AND FERTILITY IN BEEF CATTLE [PDF]

, 2002
Two regions of mitochondrial DNA, D-loop and ND-5 were characterized using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) involving 422 beef cattle of Hereford and composite breeds from Wokalup’s ...
A.J, Lymbery, J.M, Cummins, ., Sutarno, RCA, Thompson   +3 more
core  

Ribonucleotides in mitochondrial DNA [PDF]

FEBS Letters, 2019
The incorporation of ribonucleotides (rNMPs) into DNA during genome replication has gained substantial attention in recent years and has been shown to be a significant source of genomic instability. Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with regard to their rNMP ...
Wanrooij, Paulina H., Chabes, Andrei
openaire   +3 more sources

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.

PLoS Genetics, 2016
MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic ...
Ilaria Dalla Rosa, Yolanda Cámara, Romina Durigon, Chloe F Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A Johnson, Sarah Grocott, Liya Wang, David R Thorburn, Michio Hirano, Joanna Poulton, Robert W Taylor, Greg Elgar, Ramon Martí, Peter Voshol, Ian J Holt, Antonella Spinazzola   +18 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors [PDF]

, 2011
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another.
St. John Justin C., Dickinson Adam, Daniel A Mitchell, Yan Jiang, Kelly Richard, Peters Amy, Fulka, Helena, Helena Fulka, Justin C. St. John, Dickinson, Adam, St. John, Justin C., Adam Dickinson, Daniel A. Mitchell, Justin C St John, Jiang Yan, Fulka Helena, Kelly, Richard D. W., Mitchell Daniel A., Mitchell, Daniel A., Peters, Amy, Richard Kelly, Jiang, Yan, Amy Peters   +22 more
core   +1 more source

Mitochondrial DNA in osteoarthritis disease [PDF]

Clinical Rheumatology, 2020
[Abstract] Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal joint function characterized by cartilage degradation, bone remodeling, osteophyte formation, and joint inflammation [1].
Francisco J. Blanco, Ignacio Rego-Pérez
openaire   +3 more sources