Results 71 to 80 of about 920,301 (294)

Mitochondrial DNA analysis of eneolithic trypillians from Ukraine reveals neolithic farming genetic roots [PDF]

, 2017
The agricultural revolution in Eastern Europe began in the Eneolithic with the Cucuteni-Trypillia culture complex. In Ukraine, the Trypillian culture (TC) existed for over two millennia (ca. 5,400–2,700 BCE) and left a wealth of artifacts.
Lillie, Malcolm, Mallick, Swapan, Nikitin, Alexey, Nikitin, Alexey G., Potekhina, Inna, Potiekhina, I D, Reich, David, Rohland, Nadin   +7 more
core   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

Nature Communications
Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay.
Aino Heikkinen, Vivienne F. C. Esser, Seung Hyuk T. Lee, Sara Lundgren, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Sini Heinonen, Sergio Villicaña, Jordana T. Bell, Alice Maguolo, Emma Nilsson, Charlotte Ling, Allan Vaag, Päivi Pajukanta, Jaakko Kaprio, Kirsi H. Pietiläinen, Shuai Li, Miina Ollikainen   +19 more
doaj   +1 more source

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional ...
Jinmei Ye, Cong Duan, Jiaxin Han, Jinrong Chen, Ning Sun, Yuan Li, Tifei Yuan, Daihui Peng   +7 more
doaj   +1 more source

Fluorescent Visualization of In Vitro Mitochondrial DNA Transcription [PDF]

, 2019
Mitochondria are important organelles within eukaryotic cells especially for their role in metabolism and ATP production by the oxidative phosphorylation (OXPHOS) pathway. In human cells there are approximately 80 protein subunits that make up the OXPHOS
Bruce, Kelsey
core   +1 more source

Archaic mitochondrial DNA inserts in modern day nuclear genomes

, 2019
Traces of interbreeding of Neanderthals and Denisovans with modern humans in the form of archaic DNA have been detected in the genomes of present-day human populations outside sub-Saharan Africa.
Bücking, R., Cox, M., Hudjashov, G., Saag, L., Stoneking, M., Sudoyo, H.   +5 more
core   +1 more source

Failure to detect "cap" structures in mitochondrial DNA-coded poly(A)-containing RNA from HeLa cells [PDF]

, 1978
The structure of the 5'-termini has been investigated in mitochondrial DNA- coded poly(A)-containing RNA from HeLa cells. For this purpose, mitochondrial RNA isolated from cells labeled for 3 hours with [32P]orthophosphate in the presence of 20 µg/ml ...
Amalric, François, Attardi, Giuseppe, Crews, Stephen, Grohmann, Karel   +3 more
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Identification of Birds through DNA Barcodes [PDF]

, 2004
Short DNA sequences from a standardized region of the genome provide a DNA barcode for identifying species. Compiling a public library of DNA barcodes linked to named specimens could provide a new master key for identifying species, one whose power will ...
, Ankney, Avise, Avise, Avise, Avise, Avise, Banks, Banks, Banks, Bates, Bensasson, Blaxter, Brown, Charles Godfray, , Charles M Francis, Crochet, Crochet, Dove, Funk, Gill, Grant, Guglich, Hackett, Hebert, Hebert, Holder, Janzen, Johns, Kimura, Klicka, Lee, Mark Y Stoeckle, Michael, Mila, Miller, Mindell, Moore, Murray, Omland, Palumbi, Paul D. N Hebert, Pereira, Phuc, Ryan, Saitou, Sorenson, Stoeckle, Symondson, Thalmann, Tyler S Zemlak, Weibel, Wilson, Woese, Woese, Zink, Zink, Zink, Zink   +58 more
core   +7 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source