Results 221 to 230 of about 552,043 (357)

Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease [PDF]

Alexander V. Blagov, Anton Y. Postnov, Vasily N. Sukhorukov, Mikhail А. Popov, Jamol Uzokov, Alexander N. Orekhov   +5 more
openalex   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies. [PDF]

J Anim Sci Biotechnol
Shen T, Li M, Sun X, Deng Z, Pitts H, Nolan D, Loor JJ, Xu C.   +7 more
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Aging and Alzheimer's: the critical role of mitochondrial dysfunction and synaptic alterations. [PDF]

Front Synaptic Neurosci
Pinky, Wali Z, Neha, Tiwari P, El-Tanani M, Rabbani SA, Parvez S.   +6 more
europepmc   +1 more source

Table 4_SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin.xlsx

Shishi Luo (3123147), Yechuan He (22052186), Yaohui He (9905769), Danling Wang (77105)   +3 more
openalex   +1 more source

Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex [PDF]

Olayemi Joseph Olajide, Ariel A. Batallán Burrowes, Igor Ferraz da Silva, Andreas Bergdahl, C. Andrew Chapman   +4 more
openalex   +1 more source

Forms of selenium in vitamin–mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue1 [PDF]

, 2018
Qing Li, Yang Jia, W. R. Burris, Phillip J. Bridges, J. C. Matthews   +4 more
openalex   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source