Results 241 to 250 of about 541,087 (305)

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Unraveling the role of mitochondrial dysfunction in diabetic kidney disease: insights and interventions. [PDF]

Front Pharmacol
Fan Z, Luo P, Gao Y, Ma H, Fan J, Sanan S, Zhang P, Lu K, Xia H.   +8 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Mitochondrial dysfunction in PRRSV-2-infected macrophages. [PDF]

Front Immunol
Vu Manh TP, Frias-De-Diego A, Williams A, Byrne J, Sirisereewan C, Hicks J, Liu HC, Crisci E.   +7 more
europepmc   +1 more source

Mitochondrial dysfunction drives natural killer cell dysfunction in systemic lupus erythematosus. [PDF]

JCI Insight
Fluder N, Humbel M, Recazens E, Jourdain AA, Ribi C, Tsokos G, Comte D.   +6 more
europepmc   +1 more source

The Potential Role of β-Asarone in Calcium Imbalance and Mitochondrial Dysfunction in Melanoma Cells. [PDF]

Ann Dermatol
Liu Y, Tang W, Yu B, Yang Q, Lai W.
europepmc   +1 more source

miR-214-3p exacerbates mitochondrial dysfunction in parkinson's disease: a multi-omics and mechanistic study. [PDF]

Exp Brain Res
Wang X, Wang D, Zhang C, Zhang H, Wang W, Qian W, Zhou J, Zhao Y, Gao J, Hu Z, Qin J, Wang Z, Zheng Y, Yin G, Dong H.   +14 more
europepmc   +1 more source