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Mitochondrial dysfunction in aging
Ageing Research Reviews, 2023Aging is a complex process that features a functional decline in many organelles. Although mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of mitochondrial quality control (MQC) in aging is still poorly understood.
Teng Guan, Meiyu Li, Jiming Kong
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Mitochondrial dysfunction in epilepsy
Mitochondrion, 2012Mitochondrial dysfunction has been identified as one potential cause of epileptic seizures. Impaired mitochondrial function has been reported for the seizure focus of patients with temporal lobe epilepsy and Ammon's horn sclerosis and of adult and immature animal models of epilepsy.
Jaroslava Folbergrová, Wolfram S Kunz
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
Hypoergos-energy deficiency, i.e., a mismatch between the body's (tissue, organ, cell) need for energy and the limited amount of macroergs (ATP) that can currently be used to maintain the structural integrity and functional activity of a tissue or organ.
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Hypoergos-energy deficiency, i.e., a mismatch between the body's (tissue, organ, cell) need for energy and the limited amount of macroergs (ATP) that can currently be used to maintain the structural integrity and functional activity of a tissue or organ.
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Mitochondrial dysfunction in sepsis
Current Infectious Disease Reports, 1999The current mainstream view of organ failure induced by sepsis revolves around inflammation and loss of vascular control. However, there has been a resurgence in interest in bioenergetic failure due to mitochondrial dysfunction. This concept is not new--studies date back 30 years; however, the data have been highly conflicting with findings of either ...
M, Singer, D, Brealey
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ApoE and mitochondrial dysfunction
Neurology, 2020Alzheimer disease (AD) is the leading cause of dementia in the elderly, affecting more than 5.4 million individuals in the United States. AD is associated with progressive neuronal loss in the cortex and hippocampus, accompanied by extracellular amyloid plaques containing amyloid-β (Aβ) deposits, and intracellular neurofibrillary tangles.
Lixia, Qin +2 more
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Mitochondrial dysfunction in reproduction
Mitochondrion, 2004The mitochondrial genome passes from one generation to the next by way of the egg's cytoplasm, so ordinarily an individual's mitochondrial DNA (mtDNA) is entirely derived from his or her mother. A potential mother has a finite number of eggs, or oocytes, all of which were formed when she herself was still a fetus, many years before she can conceive ...
Robert P S, Jansen, Graham J, Burton
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Mitochondrial Dysfunction in Atherosclerosis
DNA and Cell Biology, 2019Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These components also play important roles in cell homeostasis by regulating cell function and phenotypic modulation. Atherosclerosis is the leading cause of morbidity and mortality in developed and developing countries.
Wenxi, Peng +7 more
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