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Mitochondrial Dysfunction in Schizophrenia
BioEssays, 2020AbstractSchizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations worldwide with a grave disability and socioeconomic burden. Current antipsychotic medications are effective treatments for positive symptoms, but poorly address negative symptoms and cognitive symptoms, warranting the development of better treatment options.
Peiyan Ni, Sangmi Chung
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Mitochondrial dysfunction in sepsis
Current Infectious Disease Reports, 1999The current mainstream view of organ failure induced by sepsis revolves around inflammation and loss of vascular control. However, there has been a resurgence in interest in bioenergetic failure due to mitochondrial dysfunction. This concept is not new--studies date back 30 years; however, the data have been highly conflicting with findings of either ...
M, Singer, D, Brealey
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Mitochondrial dysfunction in reproduction
Mitochondrion, 2004The mitochondrial genome passes from one generation to the next by way of the egg's cytoplasm, so ordinarily an individual's mitochondrial DNA (mtDNA) is entirely derived from his or her mother. A potential mother has a finite number of eggs, or oocytes, all of which were formed when she herself was still a fetus, many years before she can conceive ...
Robert P S, Jansen, Graham J, Burton
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ApoE and mitochondrial dysfunction
Neurology, 2020Alzheimer disease (AD) is the leading cause of dementia in the elderly, affecting more than 5.4 million individuals in the United States. AD is associated with progressive neuronal loss in the cortex and hippocampus, accompanied by extracellular amyloid plaques containing amyloid-β (Aβ) deposits, and intracellular neurofibrillary tangles.
Lixia, Qin +2 more
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Mitochondrial Dysfunction in Atherosclerosis
DNA and Cell Biology, 2019Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These components also play important roles in cell homeostasis by regulating cell function and phenotypic modulation. Atherosclerosis is the leading cause of morbidity and mortality in developed and developing countries.
Wenxi, Peng +7 more
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Mitochondrial dysfunction in ALS
Progress in Neurobiology, 2012In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease due to loss of upper motor neurons in cerebral cortex and lower motor neurons in brainstem and spinal cord.
Cozzolino Mauro, Carri Maria Teresa
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Mitochondrial dysfunction in the pathogenesis of endothelial dysfunction
Molecular and Cellular Biochemistry, 2023Cardiovascular diseases (CVDs) are a matter of concern worldwide, and mitochondrial dysfunction is one of the major contributing factors. Vascular endothelial dysfunction has a major role in the development of atherosclerosis because of the abnormal chemokine secretion, inflammatory mediators, enhancement of LDL oxidation, cytokine elevation, and ...
Suresh Kumar, Prajapat +2 more
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Mitochondrial Dysfunction in Neurodegeneration
Journal of Bioenergetics and Biomembranes, 1997Numerous toxins are known to interfere with mitochondrial respiratory chain functions. Use has been made of these in the development of pesticides and herbicides, and accidental use in man has led to the development of animal models for human disease. The propensity for mitochondrial toxins to induce neuronal cell death may well reflect not only their ...
J M, Cooper, A H, Schapira
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Mitochondrial dysfunction in obesity
Life Sciences, 2018Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction.
Gislaine Tezza Rezin +2 more
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Mitochondrial Dysfunction in Migraine
Seminars in Pediatric Neurology, 2013Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and
William R, Yorns, H Huntley, Hardison
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