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Mitochondrial dysfunction in obesity
Life Sciences, 2018Obesity leads to various changes in the body. Among them, the existing inflammatory process may lead to an increase in the production of reactive oxygen species (ROS) and cause oxidative stress. Oxidative stress, in turn, can trigger mitochondrial changes, which is called mitochondrial dysfunction.
Aline Haas De Mello +2 more
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Mitochondrial dysfunction in ALS
Progress in Neurobiology, 2012In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease due to loss of upper motor neurons in cerebral cortex and lower motor neurons in brainstem and spinal cord.
Cozzolino Mauro, Carri Maria Teresa
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Mitochondrial dysfunction in the pathogenesis of endothelial dysfunction
Molecular and Cellular Biochemistry, 2023Cardiovascular diseases (CVDs) are a matter of concern worldwide, and mitochondrial dysfunction is one of the major contributing factors. Vascular endothelial dysfunction has a major role in the development of atherosclerosis because of the abnormal chemokine secretion, inflammatory mediators, enhancement of LDL oxidation, cytokine elevation, and ...
Suresh Kumar, Prajapat +2 more
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Mitochondrial Dysfunction in Schizophrenia
BioEssays, 2020AbstractSchizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations worldwide with a grave disability and socioeconomic burden. Current antipsychotic medications are effective treatments for positive symptoms, but poorly address negative symptoms and cognitive symptoms, warranting the development of better treatment options.
Peiyan Ni, Sangmi Chung
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Mitochondrial dysfunction in cancer
Mitochondrion, 2004Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence.
Josephine S, Modica-Napolitano +1 more
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Mitochondrial Dysfunction in Migraine
Seminars in Pediatric Neurology, 2013Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and
William R, Yorns, H Huntley, Hardison
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Mitochondrial dysfunction and age
Current Opinion in Clinical Nutrition and Metabolic Care, 2007Mitochondrial dysfunction is commonly thought to result from oxidative damage that leads to defects in the electron transport chain (ETC). In this review, we highlight new research indicating that there are early changes in mitochondrial function that precede ETC defects and are reversible thereby providing the possibility of slowing the tempo of ...
Kevin E, Conley +2 more
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Mitochondrial Dysfunction in Gliomas
Seminars in Pediatric Neurology, 2013Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation to glycolysis ("Warburg effect"), disturbances in mt membrane potential regulation and apoptotic signaling, as well as to somatic mutations involving the Krebs cycle enzyme isocitrate ...
Christos D, Katsetos +2 more
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Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection
Biochimica Et Biophysica Acta - Bioenergetics, 2017 Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated by dysfunctional mitochondria can bring about global changes in gene expression that alters cell morphology and function. Typically, this is attributed to disruption of important mitochondrial functions, such as ATP production, integration of metabolism ...
Satish Srinivasan +2 more
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Mitochondrial Dysfunction in Neurodegeneration
Journal of Bioenergetics and Biomembranes, 1997Numerous toxins are known to interfere with mitochondrial respiratory chain functions. Use has been made of these in the development of pesticides and herbicides, and accidental use in man has led to the development of animal models for human disease. The propensity for mitochondrial toxins to induce neuronal cell death may well reflect not only their ...
J M, Cooper, A H, Schapira
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