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Mitochondrial dysfunction in cancer
Mitochondrion, 2004Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence.
Josephine S, Modica-Napolitano +1 more
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Mitochondrial dysfunction and age
Current Opinion in Clinical Nutrition and Metabolic Care, 2007Mitochondrial dysfunction is commonly thought to result from oxidative damage that leads to defects in the electron transport chain (ETC). In this review, we highlight new research indicating that there are early changes in mitochondrial function that precede ETC defects and are reversible thereby providing the possibility of slowing the tempo of ...
Kevin E, Conley +2 more
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Mitochondrial Dysfunction and Glaucoma
Journal of Glaucoma, 2009Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Open angle glaucoma prevalence and incidence increase exponentially with increasing age, yet the pathophysiology underlying increasing age as a risk factor for glaucoma is not well understood ...
George Y X, Kong +3 more
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Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection
Biochimica Et Biophysica Acta - Bioenergetics, 2017 Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated by dysfunctional mitochondria can bring about global changes in gene expression that alters cell morphology and function. Typically, this is attributed to disruption of important mitochondrial functions, such as ATP production, integration of metabolism ...
Narayan G Avadhani +2 more
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Mitochondrial Dysfunction in Gliomas
Seminars in Pediatric Neurology, 2013Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation to glycolysis ("Warburg effect"), disturbances in mt membrane potential regulation and apoptotic signaling, as well as to somatic mutations involving the Krebs cycle enzyme isocitrate ...
Christos D, Katsetos +2 more
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Mitochondrial Dysfunction in Autism
Seminars in Pediatric Neurology, 2013Using data of the current prevalence of autism as 200:10,000 and a 1:2000 incidence of definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder (ASD) and mt disease, it would be expected that 1 in 110 subjects with mt disease would have ASD and 1 in 2000 individuals with ASD would have mt disease.
Agustín, Legido +2 more
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Mitochondrial dysfunction in osteoarthritis
Mitochondrion, 2004In osteoarthritis (OA) a time or age dependent process leads to aberrant cartilage structure which is characterized by reduced number of chondrocytes, loss of existing cartilage extracellular matrix, the production of matrix with abnormal composition and pathologic matrix calcification.
Francisco J, Blanco +2 more
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Mitochondrial Dysfunction in Epilepsy
Seminars in Pediatric Neurology, 2013Epilepsy is the most common neurologic disorder worldwide and is characterized by recurrent unprovoked seizures. The mitochondrial (mt) respiratory chain is the final common pathway for cellular energy production through the process of oxidative phosphorylation.
Divya S, Khurana +3 more
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Mitochondrial Dysfunction in Hepatitis C
Journal of Clinical Gastroenterology, 2005Chronic hepatitis C induces a state of hepatic oxidative stress that is more pronounced than that present in many other inflammatory liver diseases. This review summarizes recent information that the hepatitis C virus (HCV) core protein plays an important role in this phenomenon.
Masaaki, Korenaga +5 more
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Mitochondrial dysfunction in bipolar disorder
2010Phosphorus magnetic resonance spectroscopic studies in bipolar disorder revealed altered brain energy metabolism resembling that of chronic progressive external ophthalmoplegia (CPEO). Mood disorder is one characteristic symptom in several families of CPEO caused by mutations of three genes, ANT1, Twinkle, and POLG.
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