Results 231 to 240 of about 1,859,766 (381)

Aging and Alzheimer's: the critical role of mitochondrial dysfunction and synaptic alterations. [PDF]

Front Synaptic Neurosci
Pinky, Wali Z, Neha, Tiwari P, El-Tanani M, Rabbani SA, Parvez S.   +6 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Nanomedicines Against Mitochondrial Dysfunction-Induced Metabolic Diseases. [PDF]

Adv Sci (Weinh)
Xu K, Wang L, Lv T, Jin C, Wu Q, Zhou Y, Xu G, Duan Z, Luo K, Yang J.   +9 more
europepmc   +1 more source

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease [PDF]

Yi Sak Kim, Soo‐Ho Choi, Keunyoung Kim, Juliana M. Navia‐Pelaez, Guy Perkins, Seunghwan Choi, Jungsu Kim, Nicolaus Nazarenkov, Robert A. Rissman, Won‐Kyu Ju, Mark H. Ellisman, Yury I. Miller   +11 more
openalex   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Multidimensional study on mitochondrial dysfunction in pulmonary hypertension. [PDF]

Front Med (Lausanne)
Yuan X, Zhang Y, Liu Y, Guo X, Jia S, Xiong X, Sun X, Jin Z.   +7 more
europepmc   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease. [PDF]

NPJ Aging
Hruby AJ, Higuchi-Sanabria R.
europepmc   +1 more source

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

Progress in retinal and eye research, 2020
K. Kaarniranta, H. Uusitalo, J. Błasiak, S. Felszeghy, R. Kannan, A. Kauppinen, A. Salminen, D. Sinha, D. Ferrington   +8 more
semanticscholar   +1 more source

Mitochondrial Dysfunction as a Neurobiological Subtype of Autism Spectrum Disorder

, 2014
Suzanne Goh, Zhengchao Dong, Yudong Zhang, Salvatore DiMauro, Bradley S. Peterson   +4 more
openalex   +2 more sources