Results 101 to 110 of about 1,628,733 (342)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

BioMed Research International, 2015
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system has been widely used for nuclear DNA editing to generate mutations or correct specific disease alleles.
Areum Jo, Sangwoo Ham, G. Lee, Yun-il Lee, Sang-Seong Kim, Yun-Song Lee, Joo-Ho Shin, Yunjong Lee   +7 more
semanticscholar   +1 more source

Mitochondrial DNA: A disposable genome?

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015
In mammalian cells, mitochondria are the only organelles besides the nucleus that house genomic DNA. The mammalian mitochondrial genome is represented by prokaryotic-type, circular, highly compacted DNA molecules. Today, more than a half-century after their discovery, the biology of these small and redundant molecules remains much less understood than ...
Shokolenko, Inna N., Alexeyev, Mikhail F.   +1 more
openaire   +2 more sources

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Sequencing and phylogenetic analysis of the complete mitochondrial genome of the Eurasian Harvest Mouse (Micromys minutus) Pallas 1771 from China

Mitochondrial DNA. Part B. Resources
This study aimed to examine the complete mitochondrial genome sequence of the Eurasian Harvest Mouse (Micromys minutus) through polymerase chain reaction. The mitochondrial genome of M.
Hong-Yan Wang, Yu-Qi Wu, Zhi-Hui Zhang, Zhu Liu   +3 more
doaj   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Patterns of natural selection acting on the mitochondrial genome of a locally adapted fish species

Genetics Selection Evolution, 2015
BackgroundMitochondrial DNA (mtDNA) is frequently used in population genetic studies and is usually considered as a neutral marker. However, given the functional importance of the proteins encoded by the mitochondrial genome, and the prominent role of ...
S. Consuegra, E. John, E. Verspoor, C. G. de Leaniz   +3 more
semanticscholar   +1 more source

Genome Digging: Insight into the Mitochondrial Genome of Homo

PLoS ONE, 2010
A fraction of the Neanderthal mitochondrial genome sequence has a similarity with a 5,839-bp nuclear DNA sequence of mitochondrial origin (numt) on the human chromosome 1. This fact has never been interpreted. Although this phenomenon may be attributed to contamination and mosaic assembly of Neanderthal mtDNA from short sequencing reads, we explain the
Igor V. Ovchinnikov, Olga I. Kholina
openaire   +5 more sources

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

The complete mitochondrial genome of Hericium coralloides (Hericiaceae, Basidiomycota)

Mitochondrial DNA. Part B. Resources, 2017
In this study, the complete mitochondrial genome of the medicinal mushroom Hericium coralloides (Hericiaceae, Basidiomycota) was sequenced. This mitochondrial genome is 72,961 bp in length and consisted of 14 protein-coding genes, 21 hypothetical open ...
Caixia Zhang, Changshan Li, Weixing Ye, Manjun Yang   +3 more
doaj   +1 more source