Results 81 to 90 of about 328,957 (317)

The mitochondrial genome of soybean reveals complex genome structures and gene evolution at intercellular and phylogenetic levels. [PDF]

PLoS ONE, 2013
Determining mitochondrial genomes is important for elucidating vital activities of seed plants. Mitochondrial genomes are specific to each plant species because of their variable size, complex structures and patterns of gene losses and gains during ...
Shengxin Chang, Yankun Wang, Jiangjie Lu, Junyi Gai, Jijie Li, Pu Chu, Rongzhan Guan, Tuanjie Zhao   +7 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The complete mitochondrial genome sequence of Triplophysa bleekeri (Teleostei, Balitoridae, Nemacheilinae)

, 2013
The genus Triplophysa (plateau loach) is a highly diverse group in the family Balitoridae with 133 valid species, and they play an important role in zoogeographic study of the Qinghai-Tibet Plateau.
Wang, Zhijian, Peng, Zuogang, Tang, Qiongying, Huang, Jing, Huang, Yan, Peng, ZG (reprint author), Southwest Univ, Sch Life Sci, Key Lab Aquat Sci Chongqing, Key Lab Freshwater Fish Reprod & Dev,Minist Educ, Chongqing 400715, Peoples R China., Wang, Jinjin   +6 more
core   +1 more source

Molecular model of the mitochondrial genome segregation machinery in Trypanosoma brucei [PDF]

, 2018
Significance Mitochondrial genome replication and segregation are essential processes in most eukaryotic cells. While replication has been studied in some detail, much less is known about the molecular machinery required to ...
Camille Peitsch, Sue Vaughan, Sandro Käser, Vaughan, Sue, André Schneider, Torsten Ochsenreiter, Jakob, Martin, Benoît Zuber, Zuber, Benoît, Käser, Sandro, Ochsenreiter, Torsten, Peitsch, Camille, Týč, Jiří, Anneliese Hoffmann, Simona Amodeo, Peitsch, Camille Françoise, Martin Jakob, Jiří Týč, Schneider, André, Hoffmann, Anneliese, Amodeo, Simona   +20 more
core   +1 more source

Transmission of the human mitochondrial genome [PDF]

Human Reproduction, 2000
The segregation and transmission of mitochondrial genomes in humans are complicated processes, but are particularly important for understanding the inheritance and clinical abnormalities of mitochondrial disorders. This review describes three aspects of mitochondrial genetics.
N, Howell, P F, Chinnery, S S, Ghosh, E, Fahy, D M, Turnbull   +4 more
openaire   +3 more sources

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

The simple de novo mitochondrial genome assembly pipeline for the Taiwanese macaque mitochondrial genome.

, 2015
The simple de novo mitochondrial genome assembly pipeline for the Taiwanese macaque mitochondrial genome.
Yu-Tai Wang (763247), David Glenn Smith (28314), Kuo Ping Chiu (18552), Yu-Feng Huang (498640), Mohit Midha (168457), Tzu-Han Chen (763246), Kurtis Jai-Chyi Pei (358271)   +6 more
core   +1 more source

Failure is not an option – mitochondrial genome segregation in trypanosomes [PDF]

, 2018
Unlike most other model eukaryotes, Trypanosoma brucei and its relatives have a single mitochondrion with a single-unit mitochondrial genome that is termed kinetoplast DNA (kDNA). Replication of the kDNA is coordinated with the cell cycle.
Schneider, André, Ochsenreiter, Torsten
core   +1 more source

MitoIMP: A Computational Framework for Imputation of Missing Data in Low-Coverage Human Mitochondrial Genome

Bioinformatics and Biology Insights, 2019
The incompleteness of partial human mitochondrial genome sequences makes it difficult to perform relevant comparisons among multiple resources. To deal with this issue, we propose a computational framework for deducing missing nucleotides in the human ...
Koji Ishiya, Fuzuki Mizuno, Li Wang, Shintaroh Ueda   +3 more
doaj   +1 more source