Results 121 to 130 of about 1,817,069 (382)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The mitochondrial genome of soybean reveals complex genome structures and gene evolution at intercellular and phylogenetic levels. [PDF]

PLoS ONE, 2013
Determining mitochondrial genomes is important for elucidating vital activities of seed plants. Mitochondrial genomes are specific to each plant species because of their variable size, complex structures and patterns of gene losses and gains during ...
Shengxin Chang, Yankun Wang, Jiangjie Lu, Junyi Gai, Jijie Li, Pu Chu, Rongzhan Guan, Tuanjie Zhao   +7 more
doaj   +1 more source

The mitochondrial genome map of Nelumbo nucifera reveals ancient evolutionary features

Scientific Reports, 2016
Nelumbo nucifera is an evolutionary relic from the Late Cretaceous period. Sequencing the N. nucifera mitochondrial genome is important for elucidating the evolutionary characteristics of basal eudicots. Here, the N.
Songtao Gui, Zhihua Wu, Hongyuan Zhang, Yinzhen Zheng, Zhixuan Zhu, Dequan Liang, Yi Ding   +6 more
semanticscholar   +1 more source

Interrogation of modern and ancient genomes reveals the complex domestic history of cattle [PDF]

, 2014
The analysis of mitochondrial and nuclear DNA sequence polymorphisms from modern cattle populations has had a profound impact on our understanding of the events surrounding the domestication of cattle.
Achilli, Achilli, Allchin, Allchin, Anderung, Baig, Baker, Bandelt, Bar-Yosef, Beja-Pereira, Bollongino, Bollongino, Bovine Genome Sequencing and Analysis Consortium, Bovine HapMap Consortium, Bradley, Bradley, Brown, Budiansky, Bökönyi, Bökönyi, Carvajal-Carmona, Chen, Clason, Clutton-Brock, Cymbron, de Alba, Decker, Decker, Delgado, Diamond, Dolukhanov, Edwards, Edwards, Edwards, Edwards, Egito, Epstein, FAO, Freeman, Freeman, Gautier, Gautier, Ginja, Giovambattista, Green, Grigson, Grigson, Grigson, Guintard, Götherström, Hanotte, Helmer, Ho, Hourani, Kantanen, Kruglyak, Lai, Larkin, Lenstra, Liron, Loftus, Loftus, MacHugh, MacHugh, MacHugh, Magee, Magee, Maillard, Maillard, Mannen, Marshall, Marshall, Martinez, Matukumalli, McTavish, Meadow, Meadow, Melander, Miller, Miller, Miretti, Mirol, Misra, Naik, Nielsen, Orlando, Paneto, Payne, Pilgrim, Primo, Qanbari, Ramey, Reingruber, Rosenbaum, Rothammer, Rouse, Rowley-Conwy, Shapiro, Smith, Soares, Stock, Stock, Svensson, Tresset, Troy, Uerpmann, Underhill, Utsunomiya, Vavilov, Waterbolk, Wendorf, Wendorf, Wilkins, Zeder, Zeuner, Zhang, Zilhao   +116 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Sharing of heteroplasmies between human liver lobes varies across the mtDNA genome

, 2019
Mitochondrial DNA (mtDNA) heteroplasmy (intra-individual variation) varies among different human tissues and increases with age, suggesting that the majority of mtDNA heteroplasmies are acquired, rather than inherited.
Eis-Hübinger, A., Hübner, A., Li, M., Madea, B., Schröder, R., Stoneking, M., Wachsmuth, M.   +6 more
core   +1 more source

Overproduction of PDR3 Suppresses Mitochondrial Import Defects Associated with a TOM70 Null Mutation by Increasing the Expression of TOM72 in Saccharomyces cerevisiae [PDF]

, 2001
Most mitochondrial proteins are synthesized with cleavable amino-terminal targeting signals that interact with the mitochondrial import machinery to facilitate their import from the cytosol.
Bedwell, David M., Hájek, Petr, Koh, Julie Y.   +2 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

MitoIMP: A Computational Framework for Imputation of Missing Data in Low-Coverage Human Mitochondrial Genome

Bioinformatics and Biology Insights, 2019
The incompleteness of partial human mitochondrial genome sequences makes it difficult to perform relevant comparisons among multiple resources. To deal with this issue, we propose a computational framework for deducing missing nucleotides in the human ...
Koji Ishiya, Fuzuki Mizuno, Li Wang, Shintaroh Ueda   +3 more
doaj   +1 more source

Organellar inheritance in the green lineage: insights from Ostreococcus tauri [PDF]

, 2013
Along the green lineage (Chlorophyta and Streptophyta), mitochondria and chloroplast are mainly uniparentally transmitted and their evolution is thus clonal. The mode of organellar inheritance in their ancestor is less certain.
Adam Eyre-Walker, Baur, Birky, Bonen, Boynton, Bruen, Correns, De Clerck, Derelle, Duret, Grimsley, Guindon, Gwenael Piganeau, Hasegawa, Hill, Hill, Houliston, Hua, Huang, Hurst, Hutson, Jancek, Kurtz, Larkin, Lewis, Lewontin, Li, MacAlpine, Marin, Marshall, Maréchal, Maynard Smith, McVean, Miyamura, Muller, Nei, Ness, Olson, Piganeau, Posada, Posada, R Development Core Team, Robbens, Rodríguez-Ezpeleta, Romain Blanc-Mathieu, Sager, Sager, Sager, Simpson, Sophie Sanchez-Ferandin, Städler, Sun, Sung, Swofford, Tamura, Tamura, Tsai   +56 more
core   +1 more source