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Visualization of mitochondrial membrane potential in mammalian cells
2020Assessment of the mitochondrial membrane potential (Δψ) in living cells, although not trivial, can be used to estimate mitochondrial bioenergetic state. For this purpose, fluorescent lipophilic cations are broadly applied. These cations enter cells and accumulate primarily in the mitochondrial matrix in a Δψ-dependent manner.
Esteras, N. +4 more
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The direction of polarity of the mitochondrial trans-membrane potential
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1969Abstract The concentration of various anions in the sucrose impermeable space of ratliver mitochondria relative to the applied concentration can be used to calculate an equilibrium potential if one supposes that the anion distribution is passive. Values so calculated for anions of different net charge are about 30 mV, with the interior positive.
E J, Harris, B C, Pressman
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Measurement of Mitochondrial Membrane Potential and Proton Leak
2009The major component of mitochondrial electrochemical potential gradient of protons is the mitochondrial membrane potential (DeltaPsi), and hence it is a suitable parameter for assessment of mitochondrial function. Dissipation of the mitochondrial membrane potential causes uncoupling of the electron transport through the respiratory chain and the ...
Serviddio G., Sastre J.
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A Miniaturized Homogenous Assay of Mitochondrial Membrane Potential
ASSAY and Drug Development Technologies, 2011Mitochondrial dysfunction is increasingly associated with disease states. These organelles, responsible for adenosine triphosphate production, have been targeted for improved function in such diseases as Parkinson's, Alzheimer's, type 2 diabetes, and sarcopenia.
Aurawan, Vongs +4 more
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Preservation of Mitochondrial Membrane Potential During Anoxia
1996Mitochondria (Mt) in living cells can be intensely and selectively stained against a dark cytoplasmic background by several fluorescent cationic dyes. For example, the incorporation of Rhodamine 123 (RH123) into Mt depends on the membrane potential, accompanied by red shifts of absorption spectra and quenching of fluorescence intensity (Emaus et al ...
Y, Nomura, T, Miyao, M, Tamura
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Effects of entacapone and tolcapone on mitochondrial membrane potential
European Journal of Pharmacology, 2002Catechol-O-methyl transferase (COMT) inhibitors, entacapone and tolcapone, are used as an adjunctive treatment to L-dopa in Parkinson's disease. Based on their catechol structure, both inhibitors are potential uncoupling agents, but only tolcapone shows this effect in vitro at clinically relevant concentrations.
Kristiina, Haasio +3 more
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Mitochondrial membrane potential and ageing in Podospora anserina
Mechanisms of Ageing and Development, 2001Some filamentous fungi exhibit a limited vegetative growth with modifications in the mitochondria, suggesting the involvement of mitochondria in the process of ageing. Nevertheless, the relationship between the ability to grow or the fate of these cells relative to their mitochondrial membrane potential (Psi(mt)) level has not been investigated.
F, Koll +3 more
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Mitochondrial membrane potential and ischemic neuronal death
Neuroscience Research, 2006Mitochondria are intracellular organelles in which high energy phosphate is produced. Ischemia causes depletion of the materials necessary to produce this phosphate and strongly affects the electron transport chain. Apoptosis commences during and after ischemia.
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The mitochondrial membrane potential (Δψm) in apoptosis; an update
Apoptosis, 2003Mitochondrial dysfunction has been shown to participate in the induction of apoptosis and has even been suggested to be central to the apoptotic pathway. Indeed, opening of the mitochondrial permeability transition pore has been demonstrated to induce depolarization of the transmembrane potential (deltapsi(m)), release of apoptogenic factors and loss ...
Ly, J. D., Grubb, D. R., Lawen, A.
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Functional Significance of the Mitochondrial Membrane Potential
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2018The electrical polarization of the inner mitochondrial membrane largely determines the electrochemical potential of hydrogen ifons, being thereby a significant factor in the energy transformation during oxidation of respiratory substrates and its accumulation in the form of newly synthesized ATP.
L. D. Zorova +8 more
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