Results 251 to 260 of about 4,850,535 (301)

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Dapagliflozin Beyond Glucose Lowering: Mechanisms of Renal and Systemic Protection. [PDF]

Pathophysiology
Wise ML, Alli AA.
europepmc   +1 more source

2SAA-05 Mechanisms of protein and lipid transport in yeast mitochondria(2SAA Mitochondrial neo-biology explored from a membrane dynamics,Symposium,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Seibutsu Butsuri, 2014
openaire   +2 more sources

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Mitochondrial-endoplasmic reticulum interactions in lung diseases. [PDF]

Cell Death Dis
Zhang Y, Yan H, Peng X, Gong L, Zhang S, Liu D, Zhang C, Peng C, Li Y.   +8 more
europepmc   +1 more source

How mitochondrial heterogeneity fuels a dynamic organelle ecosystem. [PDF]

Commun Biol
Desmaison PJ, Bertolin G.
europepmc   +1 more source

The Proteome of Bone Marrow Multipotent Mesenchymal Stromal Cells Undergoes Significant Alterations in Acute Leukemia Patients at the Onset and During Treatment. [PDF]

Int J Mol Sci
Petinati NA, Sadovskaya AV, Shipounova IN, Drize NI, Vasilyeva AN, Aleshina OA, Paderina AS, Pokrovskaya OS, Kuzmina LA, Smirnov IP, Pobeguts OV, Arapidi GP, Lagarkova MA, Parovichnikova EN.   +13 more
europepmc   +1 more source

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting. [PDF]

MedComm (2020)
Ma S, Liu CQ, Ma SY, Wang SG, Xia QD, Xu MY.   +5 more
europepmc   +1 more source

Research on the amino sequence characteristics determining the transport, membrane topology and peptidase processing of mitochondrial proteins

, 2014
openaire   +1 more source

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes. [PDF]

Signal Transduct Target Ther
Wu W, Wang W, Zhang J, Liang Q, Wang N, Chen L, Wang C, Li J, Cong Y, Hong H, Cheng X, Yang M, Fang L, Kong L.   +13 more
europepmc   +1 more source