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A mitochondrial membrane hypothesis of aging

Journal of Theoretical Biology, 1987
Recently it has been demonstrated that the loss of water during aging from rat liver and heart muscle tissue is solely due to water loss from the mitochondria. A hypothesis is presented here which shows the relation between free radical attack to, and water loss from, the mitochondria and the decreased energy availability in aged cells. According to it,
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Lipid Peroxidation in Mitochondrial Membrane

1980
Publisher Summary The principal elements of cytoplasm structure and biological membranes are the phospholipids containing unsaturated fatty acid chains. The protein constituents, amino acids, nucleotides, carbohydrates, or coenzymes do not show such lability as is typical of unsaturated fatty acids in an oxygen-rich atmosphere.
Y A, Vladimirov   +3 more
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Studies of the Interaction of Mitochondrial Creatine Kinase with the Mitochondrial Membrane

1982
In this study we have investigated the binding characteristics of creatine kinase (CK) with mitochondrial membrane. Creatine kinase was found to bind membranes by electrostatic forces. At physiological pH, the interaction seems to be between positively charged groups on the enzyme protein and negatively charged groups on the membrane.
, Lipskaya TYu   +4 more
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Structure of mitochondrial cristae membranes

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1974
H J, Harmon, J D, Hall, F L, Crane
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Topography of Mitochondrial Membrane Proteins

Biochemical Society Transactions, 1975
H, Baum, J M, Wrigglesworth
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