Results 241 to 250 of about 3,790,965 (294)

The Mitochondrial Membrane

Nature, 1953
THE mitochondrial membrane has been a subject of controversy. Two distinct problems have arisen: whether a morphological membrane exists, and, if so, whether it is semi-permeable.
J L, FARRANT, R N, ROBERTSON, M J, WILKINS   +2 more
openaire   +2 more sources

Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes.

ACS Chemical Neuroscience, 2019
Aggregation of the amyloid-forming α-synuclein (αS) protein is closely associated with the etiology of Parkinson's disease (PD), the most common motor neurodegenerative disorder.
Stephanie Ghio, Angelique Camilleri, M. Caruana, Viktoria C. Ruf, F. Schmidt, A. Leonov, S. Ryazanov, C. Griesinger, Ruben J. Cauchi, F. Kamp, A. Giese, N. Vassallo   +11 more
semanticscholar   +1 more source

Mitochondrial Dynamics and Its Involvement in Disease.

Annual Review of Pathology, 2020
The dynamic properties of mitochondria-including their fusion, fission, and degradation-are critical for their optimal function in energy generation. The interplay of fusion and fission confers widespread benefits on mitochondria, including efficient ...
D. Chan
semanticscholar   +1 more source

Assembly of Mitochondrial Membranes

1994
The mitochondria of eukaryotes are highly specialized organelles that catalyze oxidative phosphorylation, providing ATP that is used by the cell to drive biosynthetic reactions and other energy-requiring processes. Many biosynthetic processes are carried out within the organelle, but most of the ATP produced by oxidative phosphorylation is exported and
E M, Ellis, G A, Reid
openaire   +2 more sources

Longevity and mitochondrial membrane potential

Biochemistry (Moscow), 2012
In Saccharomyces cerevisiae yeast cells a decrease in the mitochondrial membrane potential caused by protonophores or by a loss of mitochondrial DNA leads to an increase in longevity (replicative life span). The loss of mitochondrial DNA also activates retrograde signaling that results in certain changes in transcription. Recently, Miceli and coauthors
D A, Knorre, F F, Severin
openaire   +2 more sources

Biogenesis of mitochondrial membrane proteins

Current Opinion in Cell Biology, 2009
Mitochondria are ubiquitous, double-membrane bound organelles, which have developed from endosymbiotic alpha-proteobacteria during evolution. Outer and inner membranes of mitochondria are equipped with characteristic sets of membrane proteins required for energy conversion, metabolite and protein transport, membrane fusion and fission, and signal ...
Becker, Thomas, Gebert, Michael, Pfanner, Nikolaus, Laan, Martin van der   +3 more
openaire   +3 more sources

The arrangement of mitochondrial membranes and a new structural feature of the inner mitochondrial membranes

Journal of Ultrastructure Research, 1977
Rat heart muscle mitochondria were analyzed by means of high-resolution electron microscopy of ultrathin sections of tissue prepared according to the techniques of Sjostrand and Barajas [J. Ultrastruct. Res. 25, 121 (1968)] . These techniques aim at reducing the extent of changes in protein conformation as compared to conventional preparatory ...
openaire   +2 more sources

Electrophysiology of the inner mitochondrial membrane

Journal of Bioenergetics and Biomembranes, 1994
The application of electrophysiological techniques to mitochondrial membranes has allowed the observation and partial characterization of several ion channels, including an ATP-sensitive K(+)-selective one, a high-conductance "megachannel", a 107 pS anionic channel and three others studied at alkaline pH's.
Zoratti M, SZABO', ILDIKO'
openaire   +3 more sources

Mitochondrial Membrane Potential Assay

2022
Mitochondrial function, a key indicator of cell health, can be assessed through monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membrane potential indicator (m-MPI) to detect changes in MMP in various types of cells, such as HepG2 ...
Srilatha, Sakamuru, Jinghua, Zhao, Matias S, Attene-Ramos, Menghang, Xia   +3 more
openaire   +2 more sources

Assembling the mitochondrial outer membrane

Nature Structural & Molecular Biology, 2004
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins ...
Pfanner, Nikolaus, Wiedemann, Nils, Meisinger, Chris, Lithgow, Trevor   +3 more
openaire   +3 more sources