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A mitochondrial membrane hypothesis of aging
Journal of Theoretical Biology, 1987Recently it has been demonstrated that the loss of water during aging from rat liver and heart muscle tissue is solely due to water loss from the mitochondria. A hypothesis is presented here which shows the relation between free radical attack to, and water loss from, the mitochondria and the decreased energy availability in aged cells. According to it,
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Reaction of malonaldehyde with mitochondrial membranes
Mechanisms of Ageing and Development, 1982Malonaldehyde formed by lipid oxidation is regarded as a main crosslinker in the formation of natural age pigment. To elucidate the mechanism of pigment formation the reaction of malonaldehyde with biomembranes using fluorescence spectroscopy has been studied. Rat liver mitochondrial ghosts or bovine serum albumin were reacted with malonaldehyde.
W X, Balcavage, T K, Alvager
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Membrane structure: Binary membranes of mitochondrial cristae
Experimental Cell Research, 1969Abstract Sections of mitochondrial cristae membranes show a five-layered structure consisting of two outer and one central stained region with unstained layers between. Membranous fragments obtained by detergent fractionation of the cristae show three layers with stained layers on each side of a central unstained layer.
K S, Prezbindowski +3 more
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Lipid Peroxidation in Mitochondrial Membrane
1980Publisher Summary The principal elements of cytoplasm structure and biological membranes are the phospholipids containing unsaturated fatty acid chains. The protein constituents, amino acids, nucleotides, carbohydrates, or coenzymes do not show such lability as is typical of unsaturated fatty acids in an oxygen-rich atmosphere.
Y A, Vladimirov +3 more
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Molecular mechanisms and consequences of mitochondrial permeability transition
Nature reviews. Molecular cell biology, 2021M. Bonora, C. Giorgi, P. Pinton
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Mechanisms of Ageing and Development, 2017
L. Luévano‐Martínez +4 more
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L. Luévano‐Martínez +4 more
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Mitochondria: mitochondrial membranes in brain ageing and neurodegeneration.
International Journal of Biochemistry and Cell Biology, 2013J. Eckmann +4 more
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Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability
International Journal of Molecular Sciences, 2022Yuzhu Han, Chaowen Zhang, Hongji Wang
exaly
Mitochondrial membrane permeabilization in cell death.
Physiological Reviews, 2007G. Kroemer, L. Galluzzi, C. Brenner
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Mitochondrial membrane perturbations in cholestasis
Journal of Hepatology, 2000Rodrigues, CMP, Steer, CJ
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