Results 71 to 80 of about 3,790,965 (294)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Interaction of α-Synuclein with Vesicles that Mimic Mitochondrial Membranes

Biochimica et Biophysica Acta, 2011
α-Synuclein, an intrinsically-disordered protein associated with Parkinson’s disease, interacts with mitochondria, but the details of this interaction are unknown. We probed the interaction of α-synuclein and its A30P variant with lipid vesicles by using
Imola G. Zigoneanu, Y. Yang, A. S. Krois, M. E. Haque, G. Pielak   +4 more
semanticscholar   +1 more source

Mitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization [PDF]

Biophysical Reviews, 2017
Apoptosis is important in regulating cell death turnover and is mediated by the intrinsic and death receptor-based extrinsic pathways which converge at the mitochondrial outer membrane (MOM) leading to mitochondrial outer membrane permeabilization (MOMP).
Siti Haji, Suhaili, Hamed, Karimian, Matthew, Stellato, Tzong-Hsien, Lee, Marie-Isabel, Aguilar   +4 more
openaire   +2 more sources

Mitochondrial DNA mutations affect calcium handling in differentiated neurons. [PDF]

, 2010
Contains fulltext : 88975.pdf (Publisher’s version ) (Closed access)Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood ...
Enriquez, J.A., Turnbull, D.M., Smulders-Srinivasan, Tora, Lightowlers, R.N., Trevelyan, A.J., Nooteboom, Marco, Nooteboom, M., Smulders-Srinivasan, T.K., Smulders-Srinivasan, Tora K., Acin-Perez, Rebeca, Whittington, Miles A., Lightowlers, Robert N., Whittington, M.A., Turnbull, Doug, Kirby, Denise M., Trevelyan, Andrew, Smulders-Srinivasan, Tora K.; id_orcid, Acin-Perez, Rebecca, Trevelyan, Andrew J., Turnbull, Doug M., Acin-Perez, R., Enriquez, José Antonio, Kirby, Denise, Lightowlers, Robert, Kirby, D.M., Enriquez, Jose, Whittington, Miles   +26 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Mitochondrial porin of Neurospora crassa [PDF]

, 1987
cDNA encoding porin of Neurospora crassa, the major protein component of the outer mitochondrial membrane, was isolated and the nucleotide sequence was determined.
Kleene, Ralf, Pfanner, Nikolaus, Pfaller, Rupert, Tropschug, Maximilian, Link, Thomas A., Sebald, Walter, Neupert, Walter   +6 more
core   +1 more source

The role of cardiolipin in the structural organization of mitochondrial membranes

Biochimica et Biophysica Acta, 2009
Considerable progress has recently been made in understanding the role of cardiolipin in mitochondria. In this brief review, we discuss new data that show how cardiolipin specifically contributes to the lateral organization of mitochondrial membranes. We
M. Schlame, Mindong Ren
semanticscholar   +1 more source

TIM23-mediated insertion of transmembrane alpha-helices into the mitochondrial inner membrane [PDF]

, 2011
While overall hydrophobicity is generally recognized as the main characteristic of transmembrane (TM) alpha-helices, the only membrane system for which there are detailed quantitative data on how different amino acids contribute to the overall efficiency
Koji Yamano, Björkholm, Patrik, Kim, Hyun, von Heijne, Gunnar, Toshiya Endo, Botelho, Salomé Calado, Reichert, Andreas S., Patrik Björkholm, Kim, Hyun,, Reichert, Andreas, Endo, Toshiya, Hyun Kim, Österberg, Marie,, Salomé Calado Botelho, Marie Österberg, von Heijne, Gunnar,, Österberg, Marie, Andreas S Reichert, Björkholm, Patrik,, Yamano, Koji, Heijne, Gunnar von, Botelho, Salomé Calado,, Gunnar von Heijne   +22 more
core   +1 more source