Results 51 to 60 of about 273,845 (254)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

CancerGram: An Effective Classifier for Differentiating Anticancer from Antimicrobial Peptides

Pharmaceutics, 2020
Antimicrobial peptides (AMPs) constitute a diverse group of bioactive molecules that provide multicellular organisms with protection against microorganisms, and microorganisms with weaponry for competition.
Michał Burdukiewicz, Katarzyna Sidorczuk, Dominik Rafacz, Filip Pietluch, Mateusz Bąkała, Jadwiga Słowik, Przemysław Gagat   +6 more
doaj   +1 more source

Unique and abnormal subependymal pseudocysts in a newborn with mitochondrial disease

Science Progress, 2021
Neonatal mitochondrial disease is occasionally observed in patients with intraventricular cysts in the brain. Atypical morphology is rarely seen in these cysts. Here, we report a case of neonatal lethal mitochondrial disease with IBA57 gene mutation.
Yuki Sato, Ryoji Aoki, Nobuhiko Nagano, Chika Takano, Ayako Seimiya, Ryota Kato, Erika Ogawa, Mika Ishige, Yasushi Okazaki, Kei Murayama, Ichiro Morioka   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Ammonia production, excretion, toxicity, and defense in fish: A Review

Frontiers in Physiology, 2010
Many fishes are ammonotelic but some species can detoxify ammonia to glutamine or urea. Certain fish species can accumulate high levels of ammonia in the brain or defense against ammonia toxicity by enhancing the effectiveness of ammonia excretion ...
Alex Y K Ip, S. F Chew
doaj   +1 more source

Mitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization [PDF]

Biophysical Reviews, 2017
Apoptosis is important in regulating cell death turnover and is mediated by the intrinsic and death receptor-based extrinsic pathways which converge at the mitochondrial outer membrane (MOM) leading to mitochondrial outer membrane permeabilization (MOMP).
Siti Haji, Suhaili, Hamed, Karimian, Matthew, Stellato, Tzong-Hsien, Lee, Marie-Isabel, Aguilar   +4 more
openaire   +2 more sources

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Is VDAC2 a new target for the treatment of cardiac pathologies? (literature review)

Известия высших учебных заведений. Поволжский регион: Медицинские науки
The most modern approach to solve the problems of treating cardiac arrhythmias is to influence the intracellular mechanisms of regulation of calcium homeostasis in the cell.
A.A. Bolotskaya, V.N. Nikolenko, N.A. Rizaeva   +2 more
doaj   +1 more source

Olive oil, dietary fat and ageing, a mitochondrial approach

Grasas y Aceites, 2004
Ageing represents a great concern in developed countries because the high number of people included in this group (indeed, a further increase in the rate of old people it is expected in the near future).
José Mataix, Julio J. Ochoa, José L. Quiles   +2 more
doaj   +1 more source

Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I

BMC Biology, 2020
Background For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis.
John J. Wright, Justin G. Fedor, Judy Hirst, Maxie M. Roessler   +3 more
doaj   +1 more source