Results 31 to 40 of about 280,461 (302)

Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy

JACC: Basic to Translational Science, 2023
Summary: Mitochondrial dysfunction is suggested to be a major contributor for the progression of heart failure (HF). Here we examined the role of syntaxin 17 (STX17) in the progression of HF. Cardiac-specific Stx17 knockout manifested cardiac dysfunction
Haixia Xu, MD, Xiang Wang, MD, Wenjun Yu, MD, Shiqun Sun, MD, Ne N. Wu, MD, Junbo Ge, MD, PhD, Jun Ren, MD, PhD, Yingmei Zhang, MD, PhD   +7 more
doaj   +1 more source

Successive translocation into and out of the mitochondrial matrix [PDF]

, 1987
We investigated the import and sorting pathways of cytochrome b2 and cytochrome c1, which are functionally located in the intermembrane space of mitochondria.
Ostermann, Joachim, Hartl, Franz-Ulrich, Neupert, Walter, Guiard, Bernard   +3 more
core   +1 more source

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

Frontiers in Neuroscience, 2020
Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD). Although its role in neurotransmission is well established, the precise role of this protein
Valentina Gilmozzi, Giovanna Gentile, Maria Paulina Castelo Rueda, Andrew A. Hicks, Peter P. Pramstaller, Peter P. Pramstaller, Alessandra Zanon, Martin Lévesque, Irene Pichler   +8 more
doaj   +1 more source

A mitochondrial import receptor for the ADP/ATP carrier [PDF]

, 1990
We have identified a mitochondrial outer membrane protein of 72 kd (MOM72) that exhibits the properties of an import receptor for the ADP/ATP carrier (AAC), the most abundant mitochondrial protein.
Söllner, Thomas, Pfanner, Nikolaus, Pfaller, Rupert, Neupert, Walter, Griffiths, Gareth   +4 more
core   +1 more source

Mitochondrial Membrane Potential Assay [PDF]

, 2016
Mitochondrial function, a key indicator of cell health, can be assessed by monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membrane potential indicator (m-MPI) to detect changes in MMP in HepG2 cells.
Srilatha, Sakamuru, Matias S, Attene-Ramos, Menghang, Xia   +2 more
openaire   +2 more sources

The Many Shapes of Mitochondrial Membranes [PDF]

Traffic, 2001
The roles of mitochondria in cell death and in aging have generated much excitement in recent years. At the same time, however, a quiet revolution in our thinking about mitochondrial ultrastructure has begun. This revolution started with the use of vital dyes and of green fluorescent protein fusion proteins, showing that mitochondria are very dynamic ...
L, Griparic, A M, van der Bliek
openaire   +2 more sources

Study of the transfer of phospholipids from the endoplasmic reticulum to the outer and inner mitochondrial membranes

Journal of Lipid Research, 1971
Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
doaj   +1 more source

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
W Neupert, Lill, Roland, Harkness, Troy A.A.,, van der Klei, Ida, Neupert, Walter, Harkness, Troy A. A., Klei, Ida J. van der, TA Harkness, Klei, Ida van der,, Nargang, Frank E.,, I van der Klei, Neupert, Walter,, Lill, Roland,, van der Klei, Ida ; id_orcid, Nargang, Frank E., FE Nargang, R Lill   +16 more
core   +1 more source

Mechanisms of mitochondrial membrane permeabilization [PDF]

Cell Death & Differentiation, 2000
devoted to the topic of mitochondria andtheir role in apoptosis. The reviews are provided by some ofthe world’s leading groups working on this importantsubject.An incontrovertable role for mitochondria in inducingapoptosis and controlling cell death commitment has beenestablished. However, for the past several years, con-troversy has abounded as to the
J C, Reed, G, Kroemer
openaire   +2 more sources

Hsp70 at the membrane: driving protein translocation

BMC Biology, 2018
Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—such as those in the membranes of the ...
Elizabeth A. Craig
doaj   +1 more source