Cardiolipin-Dependent Properties of Model Mitochondrial Membranes from Molecular Simulations. [PDF]
Cardiolipin is an anionic lipid found in the mitochondrial membranes of eukaryotes ranging from unicellular microorganisms to metazoans. This unique lipid contributes to various mitochondrial functions, including metabolism, mitochondrial membrane fusion
Wilson BA, Ramanathan A, Lopez CF.
europepmc +2 more sources
Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes. [PDF]
Mitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA and are therefore involved in organization of the ...
Almannai M, Salah A, El-Hattab AW.
europepmc +4 more sources
The Maintenance of Mitochondrial DNA Integrity and Dynamics by Mitochondrial Membranes. [PDF]
Mitochondria are complex organelles that harbour their own genome. Mitochondrial DNA (mtDNA) exists in the form of a circular double-stranded DNA molecule that must be replicated, segregated and distributed around the mitochondrial network. Human cells typically possess between a few hundred and several thousand copies of the mitochondrial genome ...
Chapman J, Ng YS, Nicholls TJ.
europepmc +5 more sources
Amyloid pores in mitochondrial membranes. [PDF]
Vassallo N.
europepmc +4 more sources
Structural features and lipid binding domain of tubulin on biomimetic mitochondrial membranes. [PDF]
Hoogerheide DP +9 more
europepmc +2 more sources
Mitochondrial Membrane Remodeling [PDF]
Mitochondria are key regulators of many important cellular processes and their dysfunction has been implicated in a large number of human disorders. Importantly, mitochondrial function is tightly linked to their ultrastructure, which possesses an intricate membrane architecture defining specific submitochondrial compartments.
Ziyun Yang +22 more
openaire +3 more sources
Summary Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown. Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT)
Rui Miao +26 more
semanticscholar +1 more source
Mitochondrial membrane potential [PDF]
The mitochondrial membrane potential (ΔΨm) generated by proton pumps (Complexes I, III and IV) is an essential component in the process of energy storage during oxidative phosphorylation. Together with the proton gradient (ΔpH), ΔΨm forms the transmembrane potential of hydrogen ions which is harnessed to make ATP.
Ljubava D, Zorova +11 more
openaire +2 more sources
Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]
Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert +5 more
core +2 more sources
Dynamic Imaging of Lipid Order and Heterogeneous Microviscosity in Mitochondrial Membranes of Potato Tubers Under Abiotic Stress. [PDF]
Microviscosity and lipid order are the main parameters characterizing the phase states of the membrane. Variations in microviscosity and lipid composition in a living cell may indicate serious disturbances, including various kinds of stress. In this work,
Nurminsky VN +5 more
europepmc +2 more sources

