Results 21 to 30 of about 273,845 (254)

THE REVERSAL OF MITOCHONDRIAL MEMBRANE [PDF]

The Journal of Cell Biology, 1962
An electron microscope study of mitochondria in hamster liver and kidney cells has revealed that at some points the outer membrane of these organelles is continuous with the inner membrane. Also, at such points the discontinuous components of the membrane pairs have free endings.
openaire   +2 more sources

Protocol for engineering and validating a synthetic mitochondrial intermembrane bridge in mammalian cells

STAR Protocols, 2022
Summary: Membrane contact sites are recognized as critical means of intercompartmental communication. Here, we describe a protocol for engineering and validating a synthetic bridge between the inner and outer mitochondrial membranes to support ...
Gunjan Purohit, Martonio Ponte Viana, Oleh Khalimonchuk   +2 more
doaj   +1 more source

Naja mossambica mossambica Cobra Cardiotoxin Targets Mitochondria to Disrupt Mitochondrial Membrane Structure and Function

Toxins, 2019
Cobra venom cardiotoxins (CVCs) can translocate to mitochondria to promote apoptosis by eliciting mitochondrial dysfunction. However, the molecular mechanism(s) by which CVCs are selectively targeted to the mitochondrion to disrupt mitochondrial function
Boris Zhang, Feng Li, Zhengyao Chen, Indira H. Shrivastava, Edward S. Gasanoff, Ruben K. Dagda   +5 more
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Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover

Antioxidants, 2018
The mitochondrial network is a dynamic organization within eukaryotic cells that participates in a variety of essential cellular processes, such as adenosine triphosphate (ATP) synthesis, central metabolism, apoptosis and inflammation.
Sumaira Ali, Gavin P. McStay
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Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy

JACC: Basic to Translational Science, 2023
Summary: Mitochondrial dysfunction is suggested to be a major contributor for the progression of heart failure (HF). Here we examined the role of syntaxin 17 (STX17) in the progression of HF. Cardiac-specific Stx17 knockout manifested cardiac dysfunction
Haixia Xu, MD, Xiang Wang, MD, Wenjun Yu, MD, Shiqun Sun, MD, Ne N. Wu, MD, Junbo Ge, MD, PhD, Jun Ren, MD, PhD, Yingmei Zhang, MD, PhD   +7 more
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Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

Frontiers in Neuroscience, 2020
Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD). Although its role in neurotransmission is well established, the precise role of this protein
Valentina Gilmozzi, Giovanna Gentile, Maria Paulina Castelo Rueda, Andrew A. Hicks, Peter P. Pramstaller, Peter P. Pramstaller, Alessandra Zanon, Martin Lévesque, Irene Pichler   +8 more
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The Many Shapes of Mitochondrial Membranes [PDF]

Traffic, 2001
The roles of mitochondria in cell death and in aging have generated much excitement in recent years. At the same time, however, a quiet revolution in our thinking about mitochondrial ultrastructure has begun. This revolution started with the use of vital dyes and of green fluorescent protein fusion proteins, showing that mitochondria are very dynamic ...
L, Griparic, A M, van der Bliek
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Study of the transfer of phospholipids from the endoplasmic reticulum to the outer and inner mitochondrial membranes

Journal of Lipid Research, 1971
Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
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Mitochondrial Membrane Potential Assay [PDF]

, 2016
Mitochondrial function, a key indicator of cell health, can be assessed by monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membrane potential indicator (m-MPI) to detect changes in MMP in HepG2 cells.
Srilatha, Sakamuru, Matias S, Attene-Ramos, Menghang, Xia   +2 more
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Mechanisms of mitochondrial membrane permeabilization [PDF]

Cell Death & Differentiation, 2000
devoted to the topic of mitochondria andtheir role in apoptosis. The reviews are provided by some ofthe world’s leading groups working on this importantsubject.An incontrovertable role for mitochondria in inducingapoptosis and controlling cell death commitment has beenestablished. However, for the past several years, con-troversy has abounded as to the
J C, Reed, G, Kroemer
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