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Characterization of Translocation Contact Sites Involved in the Import of Mitochondrial Proteins [PDF]

open access: yes, 1987
Import of proteins into the mitochondrial matrix requires translocation across two membranes. Translocational intermediates of mitochondrial proteins, which span the outer and inner membrane simultaneously and thus suggest that translocation occurs in ...
Herzog, Volker   +5 more
core   +2 more sources

On the Effect of Melittin on Surface Properties of Erythrocyte and Mitochondrial Membranes. [PDF]

open access: yesMembranes (Basel)
Many biomedical applications require a detailed understanding of the action of antimicrobial peptides on biological membranes. The cationic hemolytic peptide melittin, a major component of European honey bee (Apis mellifera) venom, is considered a model ...
Doltchinkova V   +6 more
europepmc   +2 more sources

Protein translocation across mitochondrial membranes [PDF]

open access: yes, 1992
Protein translocation across biological membranes is of fundamental importance for the biogenesis of organelles and in protein secretion. We will give an overview of the recent achievements in the understanding of protein translocation across ...
Walter Neupert   +3 more
core   +1 more source

Transport of proteins across mitochondrial membranes [PDF]

open access: yes, 1994
The vast majority of proteins comprising the mitochondrion are encoded by nuclear genes, synthesized on ribosomes in the cytosol, and translocated into the various mitochondrial subcompartments. During this process proteins must cross the lipid membranes
Neupert, Walter
core   +1 more source

A morphological view on mitochondrial protein targeting [PDF]

open access: yes, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ida J. van der Klei   +5 more
core   +1 more source

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

open access: yes, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
W Neupert   +16 more
core   +3 more sources

THE REVERSAL OF MITOCHONDRIAL MEMBRANE [PDF]

open access: yesThe Journal of Cell Biology, 1962
An electron microscope study of mitochondria in hamster liver and kidney cells has revealed that at some points the outer membrane of these organelles is continuous with the inner membrane. Also, at such points the discontinuous components of the membrane pairs have free endings.
openaire   +2 more sources

Early steps in mitochondrial protein import [PDF]

open access: yes, 1990
The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Stuart, Rosemary A.   +2 more
core   +1 more source

Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

open access: yesEMBO Journal, 2017
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) that is then cleaved by γ‐secretase to generate the β‐amyloid (Aβ) found in ...
Marta Pera   +16 more
semanticscholar   +1 more source

Electrical Properties of Mitochondrial Membranes [PDF]

open access: yesThe Journal of Cell Biology, 1960
The electrical capacity of the membrane of rat liver mitochondria is 0.5 to 0.6 µ./cm2. This membrane capacity is obtained from the analysis of the frequency dependence of the admittance of a suspension of swollen mitochondria. In potassium chloride media the mitochondrial membrane capacity does not depend on the ion concentration.
H, PAULY, L, PACKER, H P, SCHWAN
openaire   +2 more sources

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