Results 41 to 50 of about 3,790,965 (294)
Mitochondrial protein organization: from biogenesis to networks and function
Nature reviews. Molecular cell biology, 2019 Mitochondria are essential for the viability of eukaryotic cells as they perform crucial functions in bioenergetics, metabolism and signalling and have been associated with numerous diseases.
N. Pfanner, B. Warscheid, Nils Wiedemann
semanticscholar +1 more source
Mitochondrial protein import [PDF]
, 1988 Transport of nuclear-encoded precursor proteins into mitochondria includes proteolytic cleavage of aminoterminal targeting sequences in the mitochondrial matrix. We have isolated the processing activity from Neurospora crassa.
Hawlitschek, Gerhard +5 more
core +1 more source
The Many Shapes of Mitochondrial Membranes [PDF]
Traffic, 2001 The roles of mitochondria in cell death and in aging have generated much excitement in recent years. At the same time, however, a quiet revolution in our thinking about mitochondrial ultrastructure has begun. This revolution started with the use of vital dyes and of green fluorescent protein fusion proteins, showing that mitochondria are very dynamic ...
L, Griparic, A M, van der Bliek
openaire +2 more sources
Mitochondrial Fusion: The Machineries In and Out.
Trends in Cell Biology, 2020 Mitochondria are highly dynamic organelles that constantly undergo fission and fusion. Disruption of mitochondrial dynamics undermines their function and causes several human diseases. The fusion of the outer (OMM) and inner mitochondrial membranes (IMM)
Song Gao, Junjie Hu
semanticscholar +1 more source
Mechanisms of mitochondrial membrane permeabilization [PDF]
Cell Death & Differentiation, 2000 devoted to the topic of mitochondria andtheir role in apoptosis. The reviews are provided by some ofthe world’s leading groups working on this importantsubject.An incontrovertable role for mitochondria in inducingapoptosis and controlling cell death commitment has beenestablished. However, for the past several years, con-troversy has abounded as to the
J C, Reed, G, Kroemer
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Biosynthetic pathway of mitochondrial ATPase subunit 9 in Neurospora crassa [PDF]
, 1983 Subunit 9 of mitochondrial ATPase (Su9) is synthesized in reticulocyte lysates programmed with Neurospora poly A-RNA, and in a Neurospora cell free system as a precursor with a higher apparent molecular weight than the mature protein (Mr 16,400 vs.
Zimmermann, Richard +3 more
core +2 more sources
International Journal of Alzheimer's Disease, 2012 Alzheimer pathogenesis involves mitochondrial dysfunction, which is closely related to amyloid-β (Aβ) generation, abnormal tau phosphorylation, oxidative stress, and apoptosis.
S. Rosales-Corral +7 more
semanticscholar +1 more source
Mitochondrial Protein Import [PDF]
, 1987 The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Pfanner, Nikolaus +2 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source