Results 121 to 130 of about 3,189,303 (248)

Permeability Transition Pore Closure Promoted By Quinine.

, 2015
The mitochondrial membrane permeability transition induced by Ca2+ is inhibited by quinine in a dose-dependent fashion. Competition experiments strongly suggest that quinine displaces Ca2+ bound to the inner membrane.
Catisti, R, Vercesi, A E
core  

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Mitochondrial non-energetic function and embryonic cardiac development

Frontiers in Cell and Developmental Biology
The initial contraction of the heart during the embryonic stage necessitates a substantial energy supply, predominantly derived from mitochondrial function. However, during embryonic heart development, mitochondria influence beyond energy supplementation.
Jingxian Shi, Yuxi Jin, Sha Lin, Xing Li, Donghui Zhang, Jinlin Wu, Yan Qi, Yifei Li   +7 more
doaj   +1 more source

Relating pore fabric geometry to acoustic and permeability anisotropy in Crab Orchard Sandstone: A laboratory study using magnetic ferrofluid [PDF]

, 2003
Pore fabric anisotropy is a common feature of many sedimentary rocks. In this paper we report results from a comparative study on the anisotropy of a porous sandstone (Crab Orchard) using anisotropy of magnetic susceptibility (AMS), acoustic wave ...
Benson, PM, Platzman, ES, Meredith, PG
core  

The mitochondrial permeability transition pore: Channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology

, 2015
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiol Rev 95: 1111–1155, 2015.
LIPPE, Giovanna, FORTE, MICHAEL ANTHONY, Bernardi, Paolo, Forte, Michael, Rasola, Andrea, Bernardi P, Rasola A, Lippe G, Forte M   +8 more
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

SPG7 (paraplegin) and the mitochondrial permeability transition pore

Frontiers in Physiology, 2015
Paolo eBernardi, Michael eForte
doaj   +1 more source

The Permeability Transition Pore as a Mitochondrial Ca2+ Release Channel; a Critical Appraisal

, 1996
Mitochondria from a variety of sources possess an inner membrane channel, the permeability transition pore. The pore is a voltage-dependent channel, activated by matrix Ca2+ and inhibited by matrix H+, which can be blocked by cyclosporin A, presumably ...
PETRONILLI V., BERNARDI, PAOLO
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore. A Critical Appraisal.

, 1997
The mitochondrial permeability transition pore, a cyclosporin A-sensitive channel, can be opened by the addition of protonophoric uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) after energy-dependent accumulation of Ca2+. We
BERNARDI, PAOLO, PETRONILLI V, SCORRANO, LUCA, Bernardi P, Scorrano L, Valeria Petronilli, Luca Scorrano, Paolo Bernardi   +7 more
core   +1 more source