Results 181 to 190 of about 3,189,303 (248)

Calcium signaling induced by 15-deoxy-prostamide-J2 promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore. [PDF]

Oncotarget, 2022
Ladin DA, Nelson MM, Cota E, Colonna C, Burns C, Robidoux J, Fisher-Wellman KH, Van Dross-Anderson R.   +7 more
europepmc   +1 more source

SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages

Advanced Science, EarlyView.
SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang   +8 more
wiley   +1 more source

Differential effects of endo- and exopolyphosphatase expression on the induction of the mitochondrial permeability transition pore. [PDF]

Biochim Biophys Acta Biomembr
Akosah Y, Hambardikar V, Neginskaya M, Morris S, Solesio ME, Pavlov EV.   +5 more
europepmc   +1 more source

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and Epac: A Role for the Mitochondrial Permeability Transition Pore. [PDF]

Int J Mol Sci, 2022
Lewis MJ, Khaliulin I, Hall K, Suleiman MS.   +3 more
europepmc   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Pharmacological restoration of mitochondrial permeability transition pore flickering by high-content drug repurposing.

Pharmacol Res
Franchini E, Bulloni M, Sorgente A, Paulikova K, Cassina L, Marafelli I, Sambri I, Pattini L, Casari G.   +8 more
europepmc   +1 more source

Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors. [PDF]

J Enzyme Inhib Med Chem
Albanese V, Pedriali G, Fabbri M, Ciancetta A, Ravagli S, Roccatello C, Guerrini R, Morciano G, Preti D, Pinton P, Pacifico S.   +10 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Cardioprotective Effect of Chronic Hypoxia Involves Inhibition of Mitochondrial Permeability Transition Pore Opening. [PDF]

Physiol Res
Alanova P, Alan L, Neckar J, Ostadal B, Kolar F.   +4 more
europepmc   +1 more source