Results 121 to 130 of about 26,194 (236)

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease [PDF]

, 2023
Mohammad Habibi, Daniel Ferguson, Sophie J. Eichler, Mandy M. Chan, Andrew LaPoint, Trevor M. Shew, Mai He, Andrew J. Lutkewitte, Joel D. Schilling, Kevin Cho, Gary J. Patti, Brian N. Finck   +11 more
openalex   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma. [PDF]

Blood Adv, 2023
Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A.   +16 more
europepmc   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition. [PDF]

Acta Physiol (Oxf), 2023
Tavoulari S, Sichrovsky M, Kunji ERS.
europepmc   +1 more source

Mitochondrial pyruvate carrier-mediated metabolism is dispensable for the classical activation of macrophages [PDF]

, 2022
Linyu Ran, Song Zhang, Pei Zhao, Jiaxing Sun, Jiaqi Zhou, Haiyun Gan, Ryoung‐Hoon Jeon, Qiang Li, Joerg Herrmann, Feilong Wang   +9 more
openalex   +1 more source

Linezolid‐mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition

Arthritis &Rheumatology, EarlyView.
Objective Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Because mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H. W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Industrial strategies to minimize glycerol formation in ethanol fermentation by conventional Saccharomyces cerevisiae

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Industrial ethanol production faces the challenge of balancing metabolic efficiency with the minimization of byproducts such as glycerol, whose formation is intensified by osmotic, thermal, oxidative, and nutritional stresses. In the literature, two main approaches stand out for modulating its synthesis: the use of genetically modified strains
Lorena M. F. Leite, Silvio R. Andrietta, Telma T. Franco   +2 more
wiley   +1 more source

The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism. [PDF]

Am J Physiol Endocrinol Metab, 2022
Yiew NKH, Finck BN.
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source