Results 121 to 130 of about 50,341 (179)

Pyruvate Transport in Isolated Cardiac Mitochondria from two Species of Amphibian Exhibiting Dissimilar Aerobic Scope: Bufo Marinus and Rana Catesbeiana

, 2007
Cardiac mitochondria were isolated from Bufo marinus and Rana catesbeiana, two species of amphibian whose cardiovascular systems are adapted to either predominantly aerobic or glycolytic modes of locomotion.
Duerr, Jeff, Tucker, Kristina
core   +1 more source

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma. [PDF]

Blood Adv, 2023
Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A.   +16 more
europepmc   +1 more source

Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier

ABSTRACTObjectiveThe mitochondrial pyruvate carrier (MPC) occupies a critical node in intermediary metabolism, prompting interest in its utility as a therapeutic target for the treatment of obesity and cardiometabolic disease. Dysregulated nutrient metabolism in adipose tissue is a prominent feature of obesity pathophysiology, yet the functional role ...
Christopher E Shannon, Terry Bakewell, Marcel J Fourcaudot, Iriscilla Ayala, Giovanna Romero, Mara Asmis, Leandro C Freitas Lima, Martina Wallace, Luke Norton   +8 more
openaire   +2 more sources

Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition. [PDF]

Acta Physiol (Oxf), 2023
Tavoulari S, Sichrovsky M, Kunji ERS.
europepmc   +1 more source

Identification of the mammalian mitochondrial pyruvate carrier

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Burns, Chloe LS., Halestrap, Andrew P.
openaire   +1 more source

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. [PDF]

Sci Immunol, 2023
Zhu B, Wei X, Narasimhan H, Qian W, Zhang R, Cheon IS, Wu Y, Li C, Jones RG, Kaplan MH, Vassallo RA, Braciale TJ, Somerville L, Colca JR, Pandey A, Jackson PEH, Mann BJ, Krawczyk CM, Sturek JM, Sun J.   +19 more
europepmc   +1 more source

The Mitochondrial Pyruvate Carrier Coupling Glycolysis and the Tricarboxylic Acid Cycle Is Required for the Asexual Reproduction of <i>Toxoplasma gondii</i>. [PDF]

Microbiol Spectr, 2023
Lyu C, Chen Y, Meng Y, Yang J, Ye S, Niu Z, Ei-Debs I, Gupta N, Shen B.   +8 more
europepmc   +1 more source

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism. [PDF]

Mol Metab, 2023
Ferguson D, Eichler SJ, Yiew NKH, Colca JR, Cho K, Patti GJ, Shew TM, Lutkewitte AJ, Mukherjee S, McCommis KS, Niemi NM, Finck BN.   +11 more
europepmc   +1 more source

Loss of a Functional Mitochondrial Pyruvate Carrier in Komagataella phaffii Does Not Improve Lactic Acid Production from Glycerol in Aerobic Cultivation. [PDF]

Microorganisms, 2023
de Oliveira Junqueira AC, Moreira Melo NT, Skorupa Parachin N, Costa Paes H.   +3 more
europepmc   +1 more source

Development of novel mitochondrial pyruvate carrier inhibitors for breast cancer treatment. [PDF]

J Biol Chem
Schumacher TJ, Gardner ZS, Rumbley J, Ronayne CT, Mereddy VR.   +4 more
europepmc   +1 more source