Results 1 to 10 of about 296,841 (265)
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier [PDF]
Biomolecules, 2020 Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC).
Jean-Claude Martinou +2 more
exaly +5 more sources
HBV-Induced Pyruvate Increases Lactylation of Pyruvate Kinase M2 (PKM2) at K206 to Promote Liver Fibrosis [PDF]
PathogensWe previously demonstrated that HBV promotes liver fibrosis through the enhanced production of pyruvate. Pyruvate kinase M2 (PKM2), a key enzyme in pyruvate metabolism, plays an important role in liver fibrogenesis. Recently, lactylation of PKM2 has been
Wenxian Wen +11 more
doaj +2 more sources
Effect and Regulation of Pyruvate on Bacillomycin D Synthesis
Shipin gongye ke-ji, 2022 Objective: This paper mainly studied the effects and regulation of exogenous addition of pyruvate, overexpression of pyruvate kinase and acetyl-CoA synthase on the synthesis of Bacillomycin D. Methods: In this study, B. amyloliquefaciens fmbJ was used as
Wenjie MA +8 more
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Advantages of omics approaches for elucidating metabolic changes in diabetic peripheral neuropathy
Frontiers in Endocrinology, 2023 Various animal and cell culture models of diabetes mellitus (DM) have been established and utilized to study diabetic peripheral neuropathy (DPN). The divergence of metabolic abnormalities among these models makes their etiology complicated despite some ...
Hideji Yako +3 more
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Legume Alternative Oxidase Isoforms Show Differential Sensitivity to Pyruvate Activation
Frontiers in Plant Science, 2022 Alternative oxidase (AOX) is an important component of the plant respiratory pathway, enabling a route for electrons that bypasses the energy-conserving, ROS-producing complexes of the mitochondrial electron transport chain.
Crystal Sweetman +4 more
doaj +1 more source
Advanced Science, 2023 Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment
Luca Nagel +23 more
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Сerebroprotective effect of some phenolic acids under conditions of experimental brain ischemia
Фармация и фармакология (Пятигорск), 2020 The aim of the study was to evaluate the cerebroprotective effect of some phenolic acids under the conditions of experimental cerebral ischemia in rats.Materials and methods. The experiment was conducted on male Wistar rats weighing 220–240 g.
A. V. Voronkov +2 more
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Frontiers in Immunology, 2022 Macrophages deploy a variety of antimicrobial programs to contain mycobacterial infection. Upon activation, they undergo extensive metabolic reprogramming to meet an increase in energy demand, but also to support immune effector functions such as ...
Lisa Marie Røst +7 more
doaj +1 more source
Agronomy, 2021 In the present study, the fruit physiology and sugar-acid ratio of 24 pomelo cultivars grown in ten different locations of the subtropical region of China were measured.
Tengfei Pan +7 more
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The Pta-AckA Pathway Regulates LrgAB-Mediated Pyruvate Uptake in Streptococcus mutans
Microorganisms, 2020 Pyruvate forms the central node of carbon metabolism and promotes growth as an alternative carbon source during starvation. We recently revealed that LrgAB functions as a stationary phase pyruvate uptake system in Streptococcus mutans, the primary ...
Sang-Joon Ahn +3 more
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