Results 31 to 40 of about 191,179 (159)

Anaerobic glycolysis and oxidative stress interrelation in erythrocytes under administration of Cornus mas L. fruit extracts to rats with streptozotocin-induced diabetes mellitus

Біологічні студії
Background. In diabetes mellitus (DM), analysis of changes in the biochemical profile of erythrocytes is the important stage of complex scientific research to clarify the mechanism of action of medicinal products based on plant raw materials.
Anna Moroz, Iryna Brodyak, Alicja Z. Kucharska, Natalia Sybirna   +3 more
doaj   +1 more source

Allosteric Regulation Alters Carrier Domain Translocation in Pyruvate Carboxylase [PDF]

, 2018
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. The reaction occurs in two separate catalytic domains, coupled by the long-range translocation of a biotinylated carrier domain (BCCP). Here, we use a series
Budelier, Melissa M., Liu, Yumeng, St. Maurice, Martin, Stine, Katelyn   +3 more
core   +3 more sources

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations

Frontiers in Aging Neuroscience, 2023
A p.Y374X truncation in TARDBP was recently shown to reduce expression of TDP43 in fibroblasts isolated from ALS cases. In this follow up study focused on assessing the downstream phenotypic consequences of loss of TDP43 in the context of the truncation,
Scott P. Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J. Hamer, Lydia M. Castelli, Ya-Hui Lin, Sarah Roscoe, Nikolaos Stefanidis, Richard J. Mead, J. Robin Highley, Johnathan Cooper-Knock, Guillaume M. Hautbergue, Paul R. Heath, Janine Kirby, Pamela J. Shaw   +15 more
doaj   +1 more source

Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth

Cells
Increasing evidence has suggested that dihydrolipoamide S-acetyltransferase (DLAT), a subunit of the pyruvate dehydrogenase complex, is crucial for pyruvate metabolism and the regulation of cell death. The excessive death of granulosa cells (GCs) hinders
Liuhong Zhang, Yixuan Guo, Enyuan Huang, Jianing Lu, Tiantian Wang, Yonghua Shi, Meng Lv, Yongcai Chen, Shuo Li, Xiaolong Yuan, Jiaqi Li   +10 more
doaj   +1 more source

Targeting cancer cells using 3-bromopyruvate for selective cancer treatment

Saudi Journal of Medicine and Medical Sciences, 2017
Cancer treatment deserves more research efforts despite intensive conventional treatment modalities for many types of malignancies. Metastasis and resistance to chemotherapy and radiotherapy receive a lot of global research efforts.
Hussam H Baghdadi
doaj   +1 more source

Solution structure of a bacterial microcompartment targeting peptide and its application in the construction of an ethanol bioreactor [PDF]

, 2014
Targeting of proteins to bacterial microcompartments (BMCs) is mediated by an 18-amino-acid peptide sequence. Herein, we report the solution structure of the N-terminal targeting peptide (P18) of PduP, the aldehyde dehydrogenase associated with the 1,2 ...
Brown, Ian R., Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Lee, Matthew J., Mulvihill, Daniel P., Newnham, Sarah, Prentice, Michael B., Rowe, Michelle L., Warren, Martin J., Xue, Wei-Feng   +10 more
core   +1 more source

Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer

Frontiers in Bioscience-Landmark
Background: The SLC5A8 gene is silenced in various types of cancer, including cervical cancer; we recently demonstrated that the SLC5A8 gene is also silenced in cervical cancer by hypermethylation of the CpG island in the gene promoter.
Orlando Vargas-Sierra, Jennifer Hernández-Juárez, Perla Yaceli Uc-Uc, Luis A Herrera, Guadalupe Domínguez-Gómez, Patricio Gariglio, José Díaz-Chávez   +6 more
doaj   +1 more source

Pyruvate [PDF]

, 2018
Undergraduate ...
Castro, Jorge Tovar, Jang, Er Yearn, Truong, Nhat Quang   +2 more
core   +1 more source

Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]

, 2014
The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa, Bill, Markus, Brisson, Vanessa L, Conrad, Mark E, Feng, Xueyang, Men, Yujie, Tang, Yinjie J, Yi, Shan, Zhuang, Wei-Qin   +8 more
core   +1 more source

Serum pyruvate and lactate predict immunotherapy efficacy in advanced gastric cancer: a prospective biomarker study

Frontiers in Immunology
BackgroundWhile immunotherapy has redefined clinical paradigms for advanced gastric cancer, reliable efficacy prediction remains a critical unmet challenge.
Chang Liu, Ying Dai, Jiru Wang, Jingjing Wu, Jingjing Wu, Bin Wei, Bin Wei, Bin Wei, Bin Wei   +8 more
doaj   +1 more source