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Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
Science, 2012Letting Pyruvate In Transport of pyruvate is an important event in metabolism whereby the pyruvate formed in glycolysis is transported into mitochondria to feed into the tricarboxylic acid cycle (see the Perspective by Murphy and Divakaruni
Herzig Sébastien +7 more
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Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum
Applied Microbiology and Biotechnology, 2023Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid metabolism.
Juhong Chen +8 more
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Applied Microbiology and Biotechnology, 2016
Subcellular compartmentalization of the biosynthetic enzymes is one of the limiting factors for isobutanol production in Saccharomyces cerevisiae. Previously, it has been shown that mitochondrial compartmentalization of the biosynthetic pathway through re-locating cytosolic Ehrlich pathway enzymes into the mitochondria can increase isobutanol ...
Seong-Hee, Park +2 more
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Subcellular compartmentalization of the biosynthetic enzymes is one of the limiting factors for isobutanol production in Saccharomyces cerevisiae. Previously, it has been shown that mitochondrial compartmentalization of the biosynthetic pathway through re-locating cytosolic Ehrlich pathway enzymes into the mitochondria can increase isobutanol ...
Seong-Hee, Park +2 more
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The Role of Mitochondrial Pyruvate Carrier in Neurological Disorders
Molecular NeurobiologyThe mitochondrial pyruvate carrier (MPC) is a specific protein complex located in the inner mitochondrial membrane. Comprising a heterodimer of two homodimeric membrane proteins, mitochondrial pyruvate carrier 1 and mitochondrial pyruvate carrier 2, MPC connects cytoplasmic metabolism to mitochondrial metabolism by transferring pyruvate from the ...
Yue, Liu, Xiying, Yu, Wei, Jiang
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Identification of Mitochondrial Pyruvate Carrier Modulators to Treat Diabetes
Diabetes, 2018Recent work conducted in knockout mouse models or using small molecule modulators of the mitochondrial pyruvate carrier (MPC) have suggested that targeting this protein complex may have efficacy for treating diabetes as insulin sensitizers. To begin to identify other small molecules that interact with the MPC and could potentially be new therapeutic ...
KYLE S. MCCOMMIS +4 more
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2016
First, we studied the synthetic lethality of mitochondrial pyruvate carrier (MPC) knockout cells. Selective transport of pyruvate across the inner mitochondrial membrane (IMM) by the MPC is a fundamental step that couples cytosolic and mitochondrial metabolism.
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First, we studied the synthetic lethality of mitochondrial pyruvate carrier (MPC) knockout cells. Selective transport of pyruvate across the inner mitochondrial membrane (IMM) by the MPC is a fundamental step that couples cytosolic and mitochondrial metabolism.
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The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding
1994Pyruvate, a compound connecting the metabolic pathways in catabolism and anabolism of sugars, fatty acids and amino acids, in most cases must enter mitochondria where its further metabolism takes place. Pyruvate transport, catalysed by a specific carrier (Papa et al., 1971), occurs either due to a ΔpH dependent process (Papa & Paradies, 1974) or in an ...
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