Results 61 to 70 of about 50,341 (179)

Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]

, 2019
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio, Chichiarelli, Silvia, Eufemi, Margherita, Giamogante, Flavia, Gurtner, Aymone, Macone, Alberto, Magliocca, Fabio Massimo, Manganaro, Roberto, Maras, Bruno, Marrocco, Ilaria, Paglia, Giuliano, Patsilinakos, Alexandros, Perugia, Giacomo, Ragno, Rino, Rubini, Elisabetta   +14 more
core   +1 more source

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. [PDF]

PLoS Genetics, 2016
Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central step which links cytosolic and mitochondrial intermediary metabolism.
Benoît Vanderperre, Sébastien Herzig, Petra Krznar, Manuel Hörl, Zeinab Ammar, Sylvie Montessuit, Sandra Pierredon, Nicola Zamboni, Jean-Claude Martinou   +8 more
doaj   +1 more source

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. [PDF]

, 2019
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ...
Adams, Alfadhel, Alfadhel, Alfadhel, Aljabri, Anwar, Aronson, Arts, Attwell, Baio, Banka, Barennes, Benton, Bettendorff, Bettendorff, Biesecker, Brown, Butterworth, Butterworth, Butterworth, Calhau, Carney, Chandrakumar, Chen, Cheung, Chornyy, Chugani, Colbert, Croft, Day, De Meirleir, Fattal-Valevski, Fattal-Valevski, Fleming, Forouhi, Foulon, Foulon, Fraccascia, Fraccascia, Fraser, Frustaci, Fujita, Galvin, Ganapathy, Gangolf, Ganie, Ghaleiha, Gibson, Giulivi, Gold, Greenwood, Gu, Harel, Hiffler, Hilker, Inaba, Ishaque, Israels, Jankowska-Kulawy, Junior, Kamasak, Karabatsiakis, Kelley, Kerns, Khaw, Kitamura, Kornreich, Kril, Laforenza, Leichter, Lindhurst, Liu, Lonsdale, Lonsdale, Lonsdale, Lorber, Lu, Lukienko, Luxemburger, Lương, Ma, Magos, Mahajan, Mahmood, Martel, Martin, Mayr, McLure, Mergenthaler, Mezzar, Mimouni-Bloch, Molina, Mulholland, Mulle, Muoio, Murata, Nabokina, Nabokina, Nardone, Navarro, Nikseresht, Obrenovich, Oishi, Opdenakker, Ortega Garcia, Ortigoza-Escobar, Pepersack, Perez-Duenas, Plaitakis, Prabakaran, Prohaska, Rabie, Randle, Renthal, Rindi, Rindi, Robinson, Roust, Rubio-Lopez, Said, Schaller, Scrimshaw, Sequeira Lopes da Silva, Shi, Singleton, Siu, Skjeldal, Smidt, Society, Song, Sperringer, Spiegel, Stargrove, Subramanian, Subramanian, Sweet, Tabarki, Talwar, Thomson, Thornalley, van den Brink, Vasconcelos, Vernau, Vernau, Vimokesant, Watkins, Wendel, Whitfield, Whitfield, Wierzbicki, Williams, Yang, Zhang, Zhao, Zuccoli   +154 more
core   +2 more sources

H+ transport is an integral function of the mitochondrial ADP/ATP carrier. [PDF]

, 2019
The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP.
Angelin, Alessia, Bertholet, Ambre M, Cho, Joonseok, Chouchani, Edward T, Fedorenko, Andriy, Garrity, Ryan, Kazak, Lawrence, Kirichok, Yuriy, Long, Jonathan Z, Spiegelman, Bruce M, Terada, Naohiro, Vidoni, Sara, Wallace, Douglas C   +12 more
core   +1 more source

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Nature Communications, 2018
Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism ...
Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant, Olivier Feron   +12 more
doaj   +1 more source

Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer

Cell Reports, 2019
Summary: Most cancer cells exhibit metabolic flexibility, enabling them to withstand fluctuations in intratumoral concentrations of glucose (and other nutrients) and changes in oxygen availability.
Sunghee Park, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-yi Chang, Donald P. McDonnell   +8 more
doaj   +1 more source

Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]

, 2003
Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, N, Brustovetsky, T, Capano, M, Crompton, M, Dubinsky, JM, Purl, KJ   +5 more
core   +1 more source

Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism

G3: Genes, Genomes, Genetics, 2019
Multiple signaling pathways in the adult Drosophila enterocyte sense cellular damage or stress and signal to intestinal stem cells (ISCs) to undergo proliferation and differentiation, thereby maintaining intestinal homeostasis.
Dona R. Wisidagama, Carl S. Thummel
doaj   +1 more source

Plasmids in the aphid endosymbiont Buchnera aphidicola with the smallest genomes. A puzzling evolutionary story.

, 2006
Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario, Latorre, Amparo, Perez-Brocal, Vicente, Sabater-Muñoz, Beatriz, Silva, Francisco J   +4 more
core   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
core   +2 more sources