BMC Biology, 2020 Background The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane.
Heike Rampelt +9 more
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Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene [PDF]
, 2006 In the present study we confirm the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients.
Almeida, J. +11 more
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Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]
, 1993 Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Aronson +45 more
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The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism.
Am J Physiol Endocrinol Metab, 2022 Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved process and aberrant pyruvate metabolism is associated with and contributes to numerous human metabolic disorders including diabetes, cancer, and heart disease.
Yiew NKH, Finck BN.
europepmc +3 more sources
SLC54 Mitochondrial pyruvate carriers in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE, 2023 Pyruvate is oxidized to acetyl‐CoA by pyruvate dehydrogenase which is localized in the mitochondrial matrix. The mitochondrial pyruvate carrier (MPC) is composed of SLC54 family members (MPC1 and MPC2) [1, 5], which form functional hetero-dimers [9, 8]. The MPC is expressed in the inner mitochondrial membrane and involved in the import of pyruvate into
Calum Wilson, Sotiria Tavoulari
openaire +2 more sources
Harnessing Lactate Metabolism for Radiosensitization
Frontiers in Oncology, 2021 Cancer cells rewire their metabolism to promote cell proliferation, invasion, and metastasis. Alterations in the lactate pathway have been characterized in diverse cancers, correlate with outcomes, and lead to many downstream effects, including ...
Kevin X. Liu +4 more
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Multistationary and Oscillatory Modes of Free Radicals Generation by the Mitochondrial Respiratory Chain Revealed by a Bifurcation Analysis [PDF]
, 2012 The mitochondrial electron transport chain transforms energy satisfying cellular demand and generates reactive oxygen species (ROS) that act as metabolic signals or destructive factors.
Mark F. Schumaker +6 more
core +5 more sources
Mitochondrial pyruvate carrier in
Molecular Microbiology, 2016 SummaryPyruvate is a key product of glycolysis that regulates the energy metabolism of cells. In Trypanosoma brucei, the causative agent of sleeping sickness, the fate of pyruvate varies dramatically during the parasite life cycle. In bloodstream forms, pyruvate is mainly excreted, whereas in tsetse fly forms, pyruvate is metabolized in mitochondria ...
Jitka, Štáfková +5 more
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An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
Molecular Metabolism, 2016 Objective: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism.
Kyle S. McCommis +7 more
doaj +1 more source
Biogenesis of Mitochondrial Metabolite Carriers
Biomolecules, 2020 Metabolite carriers of the mitochondrial inner membrane are crucial for cellular physiology since mitochondria contribute essential metabolic reactions and synthesize the majority of the cellular ATP. Like almost all mitochondrial proteins, carriers have
Patrick Horten +2 more
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