Results 31 to 40 of about 50,341 (179)

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.

Cell Metab, 2022
Wenes M, Jaccard A, Wyss T, Maldonado-Pérez N, Teoh ST, Lepez A, Renaud F, Franco F, Waridel P, Yacoub Maroun C, Tschumi B, Dumauthioz N, Zhang L, Donda A, Martín F, Migliorini D, Lunt SY, Ho PC, Romero P.   +18 more
europepmc   +2 more sources

Mitochondrial pyruvate carrier 2 mitigates acute kidney injury via sustaining mitochondrial metabolism. [PDF]

Int J Biol Sci
Cisplatin, a chemotherapeutic drug, can result in acute kidney injury (AKI). Currently, there are no effective prevention methods. An incomplete understanding of the pathogenesis of AKI is a major barrier to the development of effective therapies. Metabolism reprogramming shift to glycolysis was involved in AKI pathogenesis.
Wu L, Li Q, Lu F, Qian L, Pan Y, Chen C, Huang Z, Duan S, Zhang B, Liang H, Xing C, Mao H, Yuan Y.   +12 more
europepmc   +3 more sources

Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid [PDF]

Endocrinology, 2017
Several recent studies have suggested that compounds known as endocrine-disrupting chemicals (EDCs) can promote obesity by serving as ligands for nuclear receptors, including the peroxisome proliferator-activated receptor γ (PPARγ) and the glucocorticoid receptor (GR). Thiazolidinedione insulin sensitizers, which act as ligands for PPARγ, also interact
Yana, Chen, Kyle S, McCommis, Daniel, Ferguson, Angela M, Hall, Charles A, Harris, Brian N, Finck   +5 more
openaire   +2 more sources

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

Cell Reports, 2020
Summary: Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer’s disease (AD), and the comprehension of the underlying mechanisms appears crucial to ...
Alice Rossi, Giulia Rigotto, Giulia Valente, Valentina Giorgio, Emy Basso, Riccardo Filadi, Paola Pizzo   +6 more
doaj   +1 more source

Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan

Biomolecules, 2020
As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration ...
Jane L. Buchanan, Eric B. Taylor
doaj   +1 more source

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Cell Reports, 2020
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate ...
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell   +11 more
doaj   +1 more source

Mitochondrial pyruvate carriers are required for myocardial stress adaptation

Nature Metabolism, 2020
In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle metabolism.
Yuan Zhang, Paul V. Taufalele, Jesse D. Cochran, Isabelle Robillard-Frayne, Jonas Maximilian Marx, Jamie Soto, Adam J. Rauckhorst, Fariba Tayyari, Alvin D. Pewa, Lawrence R. Gray, Lynn M. Teesch, Patrycja Puchalska, Trevor R. Funari, Rose McGlauflin, Kathy Zimmerman, William J. Kutschke, Thomas Cassier, Shannon Hitchcock, Kevin Lin, Kevin M. Kato, Jennifer L. Stueve, Lauren Haff, Robert M. Weiss, James E. Cox, Jared Rutter, Eric B. Taylor, Peter A. Crawford, E. Douglas Lewandowski, Christine Des Rosiers, E. Dale Abel   +29 more
openaire   +3 more sources

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

eLife, 2020
Mitochondria generate ATP and building blocks for cell growth and regeneration, using pyruvate as the main substrate. Here we introduce PyronicSF, a user-friendly GFP-based sensor of improved dynamic range that enables real-time subcellular quantitation ...
Robinson Arce-Molina, Francisca Cortés-Molina, Pamela Y Sandoval, Alex Galaz, Karin Alegría, Stefanie Schirmeier, L Felipe Barros, Alejandro San Martín   +7 more
doaj   +1 more source

Generation of an induced pluripotent stem cell line (BCHNCi003-A) from a patient with mitochondrial pyruvate carrier deficiency caused by biallelic MPC1 mutations

Stem Cell Research, 2023
Mitochondrial pyruvate carrier deficiency (MPYCD) is a rare mitochondrial disease characterized by developmental delay, microcephaly, growth failure, increased serum lactate with a normal lactate/pyruvate ratio.
Huafang Jiang, Chaolong Xu, Wenyan Li, Ling Zhou, Fang Fang   +4 more
doaj   +1 more source

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]

, 2017
Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y, Bloodgood, Brenda L, Buren, Caodu, Cordes, Thekla, Divakaruni, Ajit S, Fields, Jerel A, Li, Edward, Martyniuk, Kelly, Metallo, Christian M, Murphy, Anne N, Raymond, Lynn A, Reynolds, Ian J, Wallace, Martina   +12 more
core   +1 more source