Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis [PDF]
eLife, 2020 Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to maintain a constant body temperature and counteract metabolic disease.
Vanja Panic +15 more
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Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter [PDF]
Scientific Reports, 2018 The active transport of glycolytic pyruvate across the inner mitochondrial membrane is thought to involve two mitochondrial pyruvate carrier subunits, MPC1 and MPC2, assembled as a 150 kDa heterotypic oligomer.
Raghavendra Sashi Krishna Nagampalli +19 more
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Inflamed macrophages sans mitochondrial pyruvate carrier? [PDF]
Nat Metab, 2023 Yvan-Charvet L, Thorp EB.
europepmc +3 more sources
Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation [PDF]
Signal Transduction and Targeted Therapy, 2022 Yu Chen, Jingchun Wang, Yongsheng Li
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Recent Advances in Mitochondrial Pyruvate Carrier Inhibitors
Pharmaceutical FrontsThe mitochondrial pyruvate carrier (MPC) exists in the mitochondria inner membrane which transports pyruvate to the mitochondrial matrix. Evidence shows that MPC is the breakthrough point to study the regulation of basic energy metabolism, the dysfunction of which may lead to metabolic disturbance.
Yilei Huang +3 more
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Heart failure-emerging roles for the mitochondrial pyruvate carrier. [PDF]
Cell Death Differ, 2021 AbstractThe mitochondrial pyruvate carrier (MPC) is the entry point for the glycolytic end-product pyruvate to the mitochondria. MPC activity, which is controlled by its abundance and post-translational regulation, determines whether pyruvate is oxidised in the mitochondria or metabolised in the cytosol.
Fernandez-Caggiano M, Eaton P.
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Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy [PDF]
Nature Metabolism, 2020 Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy. MPC abundance was reduced in failing hypertrophic human hearts, as well as in the myocardium of mice induced to fail ...
Mariana Fernandez-Caggiano +11 more
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Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes. [PDF]
J Chem Inf Model, 2021 Pyruvate metabolism requires the mitochondrial pyruvate carrier (MPC) proteins to transport pyruvate from the intermembrane space through the inner mitochondrial membrane to the mitochondrial matrix. The lack of the atomic structures of MPC hampers the understanding of the functional states of MPC and molecular interactions with the substrate or ...
Xu L, Phelix CF, Chen LY.
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Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier. [PDF]
Sci AdvThe mitochondrial pyruvate carrier transports pyruvate, produced by glycolysis from sugar molecules, into the mitochondrial matrix, as a crucial transport step in eukaryotic energy metabolism. The carrier is a drug target for the treatment of cancers, diabetes mellitus, neurodegeneration, and metabolic dysfunction–associated steatotic liver disease. We
Sichrovsky M +21 more
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Mitochondrial pyruvate carrier function and cancer metabolism [PDF]
Current Opinion in Genetics & Development, 2016 Metabolic reprogramming in cancer supports the increased biosynthesis required for unchecked proliferation. Increased glucose utilization is a defining feature of many cancers that is accompanied by altered pyruvate partitioning and mitochondrial metabolism.
Adam J, Rauckhorst, Eric B, Taylor
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