Results 1 to 10 of about 50,272 (136)

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice [PDF]

iScience, 2023
Summary: The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo lipogenesis (DNL) when carbohydrates are abundant.
Nicole K.H. Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J. Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M. Singer, Gary J. Patti, Shawn C. Burgess, Brian N. Finck   +12 more
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Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex [PDF]

Nature Communications
The Mitochondrial Pyruvate Carrier (MPC) bridges cytosolic and mitochondrial metabolism by transporting pyruvate into mitochondria for ATP production and biosynthesis of various essential molecules.
Yingyuan Sun, Yaru Wang, Zheng Xing, Dongyu Li, Rong Wang, Baozhi Chen, Ning Zhou, Alyssa Ayala, Benjamin P. Tu, Xiaofeng Qi   +9 more
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NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes [PDF]

Biomolecules, 2023
The mitochondrial pyruvate carrier (Mpc) plays an indispensable role in the transport of pyruvates across the mitochondrial inner membrane. Despite the two distinct homologous proteins, Mpc1 and Mpc2, were identified in 2012, there are still ...
Zhen Wang, Wen Ding, Maosen Ruan, Yong Liu, Jing Yang, Huiqin Zhang, Bing Shen, Junfeng Wang, Yunyan Li   +8 more
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Association of Mitochondrial Pyruvate Carrier with the Clinical and Histological Features in Lupus Nephritis [PDF]

International Journal of Nephrology and Renovascular Disease
Huanhuan Zhu, Chen Chen, Luhan Geng, Qing Li, Chengning Zhang, Lin Wu, Bo Zhang, Suyan Duan,* Changying Xing,* Yanggang Yuan* Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University ...
Zhu H, Chen C, Geng L, Li Q, Zhang C, Wu L, Zhang B, Duan S, Xing C, Yuan Y   +9 more
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The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier [PDF]

Biomolecules, 2020
Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation.
Joséphine Zangari, Francesco Petrelli, Benoît Maillot, Jean-Claude Martinou   +3 more
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Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes [PDF]

Cell Reports, 2023
Summary: Branched-chain amino acid (BCAA) metabolism is linked to glucose homeostasis, but the underlying signaling mechanisms are unclear. We find that gluconeogenesis is reduced in mice deficient of Ppm1k, a positive regulator of BCAA catabolism, which
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian   +10 more
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Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer [PDF]

Molecular Metabolism, 2022
Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases.
Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji   +8 more
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The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease [PDF]

Biomolecules, 2023
Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy stored in this nutrient to be fully harnessed to generate ATP or
Kyle S. McCommis, Brian N. Finck
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Insights on the Quest for the Structure–Function Relationship of the Mitochondrial Pyruvate Carrier [PDF]

Biology, 2020
The molecular identity of the mitochondrial pyruvate carrier (MPC) was presented in 2012, forty years after the active transport of cytosolic pyruvate into the mitochondrial matrix was first demonstrated.
José Edwin Neciosup Quesñay, Naomi L. Pollock, Raghavendra Sashi Krishna Nagampalli, Sarah C. Lee, Vijayakumar Balakrishnan, Sandra Martha Gomes Dias, Isabel Moraes, Tim R. Dafforn, Andre Luis Berteli Ambrosio   +8 more
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UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier [PDF]

Advanced Science
Targeting NLRP3 inflammasome has been recognized as a promising therapeutic strategy for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of mitochondrial pyruvate carrier (MPC), is previously found to inhibit macrophage ...
Linyu Ran, Miao Chen, Jihui Ye, Song Zhang, Zhibing Luo, Tengfei Bai, Chenchen Qian, Quan Zhou, Mengtian Shan, Yong Chu, Joerg Herrmann, Qiang Li, Feilong Wang   +12 more
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