Results 11 to 20 of about 50,341 (179)

Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection [PDF]

Brain Sciences, 2019
The mitochondrial pyruvate carriers mediate pyruvate import into the mitochondria, which is key to the sustenance of the tricarboxylic cycle and oxidative phosphorylation.
Bor Luen Tang
doaj   +4 more sources

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1Research in Context [PDF]

EBioMedicine, 2018
Background: Mitochondrial pyruvate import via mitochondrial pyruvate carrier (MPC) is a central step in hepatic gluconeogenesis. Berberine inhibits hepatic gluconeogenesis, but the mechanism is incompletely understood.
Aiyun Li, Qun Liu, Qiang Li, Baolin Liu, Yang Yang, Ning Zhang   +5 more
doaj   +4 more sources

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy [PDF]

BMC Nephrology, 2020
Background Mitochondrial dysfunction contributes to the pathogenesis of diabetic nephropathy (DN). Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role in the transport of pyruvate into mitochondrial ...
Huanhuan Zhu, Huiting Wan, Lin Wu, Qing Li, Simeng Liu, Suyan Duan, Zhimin Huang, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan   +10 more
doaj   +3 more sources

Structure of mitochondrial pyruvate carrier and its inhibition mechanism. [PDF]

Nature
The mitochondrial pyruvate carrier (MPC) governs the entry of pyruvate-a central metabolite that bridges cytosolic glycolysis with mitochondrial oxidative phosphorylation-into the mitochondrial matrix1-5. It thus serves as a pivotal metabolic gatekeeper and has fundamental roles in cellular metabolism.
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L.   +6 more
europepmc   +4 more sources

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier [PDF]

Cell Metabolism, 2020
Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (
Kristofor A Olson, Jordan A Berg, Nathan M Krah   +2 more
exaly   +3 more sources

Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes [PDF]

EMBO Journal, 2015
At the pyruvate branch point, the fermentative and oxidative metabolic routes diverge. Pyruvate can be transformed either into lactate in mammalian cells or into ethanol in yeast, or transported into mitochondria to fuel ATP production by oxidative phosphorylation. The recently discovered mitochondrial pyruvate carrier (MPC), encoded by MPC1, MPC2, and
Jean-Claude Martinou
exaly   +3 more sources

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier [PDF]

Molecular Cell, 2014
Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical step in intermediary metabolism impacting numerous diseases. To characterize changes in mitochondrial substrate utilization in the context of compromised mitochondrial ...
Nathaniel M Vacanti, Ajit S Divakaruni, Courtney R Green   +2 more
exaly   +8 more sources

Experimental Investigations on the Structure of Yeast Mitochondrial Pyruvate Carriers

Membranes, 2022
Mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytoplasm into the mitochondrial matrix to participate in the tricarboxylic acid (TCA) cycle, which further generates the energy for the physiological activities of cells.
Ling Li, Maorong Wen, Changqing Run, Bin Wu, Bo OuYang   +4 more
doaj   +3 more sources

A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. [PDF]

Angew Chem Int Ed Engl, 2020
AbstractTarget engagement assays are crucial for establishing the mechanism‐of‐action of small molecules in living systems. Integral membrane transporters can present a challenging protein class for assessing cellular engagement by small molecules. The chemical proteomic discovery of alpha‐chloroacetamide (αCA) compounds that covalently modify cysteine‐
Yamashita Y, Vinogradova EV, Zhang X, Suciu RM, Cravatt BF.   +4 more
europepmc   +5 more sources

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

Molecular Metabolism, 2017
Objective: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial ...
Adam J. Rauckhorst, Lawrence R. Gray, Ryan D. Sheldon, Xiaorong Fu, Alvin D. Pewa, Charlotte R. Feddersen, Adam J. Dupuy, Katherine N. Gibson-Corley, James E. Cox, Shawn C. Burgess, Eric B. Taylor   +10 more
doaj   +3 more sources