Results 261 to 270 of about 210,348 (285)

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

Journal of Neurochemistry, 1995
Abstract: Dopamine, due to metabolism by monoamine oxidase or autoxidation, can generate toxic products such as hydrogen peroxide, oxygen‐derived radicals, semiquinones, and quinones and thus exert its neurotoxic effects. Intracerebroventricular injection of dopamine into rats pretreated with the monoamine oxidase nonselective inhibitor pargyline ...
D, Ben-Shachar, R, Zuk, Y, Glinka
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Bax Impairs Mitochondrial Respiration

Science's STKE, 2000
The mechanism by which the proapoptotic protein Bax exerts its effects has not been clear, although it is thought to involve alterations in mitochondrial physiology. Harris et al. report one possible reason why Bax expression is toxic in both yeast and mammalian cells.
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Effect of Ryanodine on Mitochondrial Respiration

Pharmacology, 1992
Ryanodine is a pharmacological agent that stimulates calcium leakage into the cytoplasm resulting in an increase in tension. In skeletal muscle, ryanodine acts primarily on the sarcoplasmic reticulum whereas in smooth muscle, the sites of action are less clear.
R M, Levin, N, Haugaard, D, Packard, M, Kaplan, A J, Wein   +4 more
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Action of halothane upon mitochondrial respiration

Archives of Biochemistry and Biophysics, 1971
Abstract The inhibitory action of halothane upon respiration was studied with rat liver mitochondria (RLM3), beef heart mitochondria (HBHM), and electron-transport particles (ETP). With intact mitochondrial preparations the oxidation of NADH-linked substrates but not of succinate was markedly suppressed by low concentrations of halothane ( m as ...
R A, Harris, J, Munroe, B, Farmer, K C, Kim, P, Jenkins   +4 more
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Ochratoxin A: Inhibition of Mitochondrial Respiration

Science, 1970
Ochratoxin A is a fungal metabolite which induces pathological changes in animals. The toxin was isolated from cultures of Aspergillus ochraceus and purified by thin-layer chromatography. Ochratoxin A and one of its hydrolysis products, dihydroisocoumarin, severely inhibited coupled respiration when applied at low ...
J H, Moore, B, Truelove
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Lead Effects on Corn Mitochondrial Respiration

Science, 1970
Oxidation of exogenous nicotinamide-adenine dinucleotide and succinate by corn mitochondria was measured as a function of lead chloride concentration. Lead chloride (50 to 62 micromoles per liter) stimulated oxidation of exogenous reduced nicotinamide-adenine dinucleotide by 174 to 640 percent depending on the reaction mediums, whereas lead chloride ...
D E, Koeppe, R J, Miller
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Mitochondrial respiration not required

Science Signaling, 2019
Chondrocytes survive constitutive hypoxia by suppressing mitochondrial respiration.
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ROLE OF PHOSPHOLIPIDS IN MITOCHONDRIAL RESPIRATION

Canadian Journal of Biochemistry and Physiology, 1959
The addition of heated snake venom solutions to suspensions of rat liver, kidney, or brain mitochondria results in an initial stimulation of the rate of respiration, which is approximately the same for a variety of substrates, followed by a rapid decline.The presence of phospholipase A in heated snake venom is demonstrated by the formation of ...
E, PETRUSHKA, J H, QUASTEL, P G, SCHOLEFIELD   +2 more
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Control of mitochondrial respiration in muscle

Molecular and Cellular Biochemistry, 1988
Control of mitochondrial respiration depends on ADP availability to the F1-ATPase. An electrochemical gradient of ADP and ATP across the mitochondrial inner membrane is maintained by the adenine nucleotide translocase which provides ADP to the matrix for ATP synthesis and ATP for energy-dependent processes in the cytosol.
J B, McMillin, D F, Pauly
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Control of Mitochondrial Respiration

1985
The control of the rate of respiration within cells is a complex process, central to metabolism, and exhibiting several different types of control at different levels of the overall process. The aim of this chapter is to outline some general principles of control in metabolic pathways and recent approaches to describing control; this is followed by a ...
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