Results 21 to 30 of about 210,348 (285)
Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage : meeting abstract [PDF]
, 2009 Mitochondria are essential for respiration and oxidative phosphorylation. Mitochondrial dysfunction due to aging processes is involved in pathologies and pathogenesis of a series of cardiovascular disorders. New results accumulate showing that the enzyme
Altschmied, Joachim +5 more
core +1 more source
Circadian rhythms in mitochondrial respiration [PDF]
Journal of Molecular Endocrinology, 2018 Many physiological processes are regulated with a 24-h periodicity to anticipate the environmental changes of daytime to nighttime and vice versa. These 24-h regulations, commonly termed circadian rhythms, among others control the sleep–wake cycle, locomotor activity and preparation for food availability during the active phase (daytime for humans and ...
de Goede, Paul +4 more
openaire +2 more sources
Epicatechin Stimulates Mitochondrial Activity and Selectively Sensitizes Cancer Cells to Radiation [PDF]
, 2014 Radiotherapy is the treatment of choice for solid tumors including pancreatic cancer, but the effectiveness of treatment is limited by radiation resistance.
Antwih, Deborah A +5 more
core +12 more sources
Regulation of mitochondrial permeability transition pore by PINK1 [PDF]
, 2012 Background: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Caballero, Erica +7 more
core +3 more sources
Mitochondrial respiration without ubiquinone biosynthesis [PDF]
Human Molecular Genetics, 2013 Ubiquinone (UQ), a.k.a. coenzyme Q, is a redox-active lipid that participates in several cellular processes, in particular mitochondrial electron transport. Primary UQ deficiency is a rare but severely debilitating condition. Mclk1 (a.k.a. Coq7) encodes a conserved mitochondrial enzyme that is necessary for UQ biosynthesis.
Ying, Wang, Siegfried, Hekimi
openaire +2 more sources
Nature Communications, 2023 Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Mitochondrial uncoupling protein 1 (UCP1) is activated in BAT during cold stress and dissipates mitochondrial proton motive ...
Anna Park +22 more
doaj +1 more source
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]
, 2017 Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T +9 more
core +1 more source
Superior Intrinsic Mitochondrial Respiration in Women Than in Men
Frontiers in Physiology, 2018 Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial ...
Daniele A. Cardinale +11 more
doaj +1 more source
Metabolites, 2022 Iron is an essential component for metabolic processes, including oxygen transport within hemoglobin, tricarboxylic acid (TCA) cycle activity, and mitochondrial energy transformation.
Christine Fischer +14 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mitochondrial injury of tubular epithelial cells (TECs) is the key pathogenic event underlying various kidney diseases and a potential intervening target as well.
Ying Yang +10 more
doaj +1 more source